STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rspRGntr family transcriptional regulator, rspab operon transcriptional repressor; Repressor of the rspAB operon. Acts by binding directly to the upstream region of rspA (228 aa)    
Predicted Functional Partners:
ydfZ
annotation not available
     
 0.856
yhjC
Putative dna-binding transcriptional regulator yhjc; Belongs to the LysR transcriptional regulatory family
      
 0.825
rspA
Mandelate racemase/muconate lactonizing enzyme family protein rspa; Probably involved in the degradation of homoserine lactone (HSL) or of a metabolite of HSL that signals starvation
 
  
 0.809
yegH
Inner membrane protein yegh; UPF0053 protein YegH; Putative transport protein
      
 0.678
hiuH
Hydroxyisourate hydrolase/transthyretin-related protein; Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo- 4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU)
     
 0.676
uxaB
Altronate oxidoreductase, nad-dependent; Altronate oxidoreductase; Protein involved in carbohydrate catabolic process
 
  
 0.658
mcbR
Gntr family transcriptional regulator, colanic acid and biofilm gene transcriptional regulator; Important for biofilm formation. Represses expression of McbA by binding to its promoter region, which prevents colanic acid overproduction and mucoidy
  
     0.622
feaR
Arac family transcriptional regulator, positive regulator of tyna and feab; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism
      
 0.605
yedW
Two-component system, ompr family, response regulator; Member of a two-component regulatory system HprR/HprS involved in response to hydrogen peroxide Regulates the expression of at least 5 operons, cyoABCDE, hprRS, hiuH, cusRS and cusCFBA. Bifunctional regulator that acts as an activator and a repressor
      
 0.603
ydfG
NADP-dependent dehydrogenase with broad substrate specificity acting on 3-hydroxy acids. Catalyzes the NADP-dependent oxidation of L- allo-threonine to L-2-amino-3-keto-butyrate, which is spontaneously decarboxylated into aminoacetone. Also acts on D-threonine, L-serine, D-serine, D-3-hydroxyisobutyrate, L-3-hydroxyisobutyrate, D-glycerate and L-glycerate . Able to catalyze the reduction of the malonic semialdehyde to 3-hydroxypropionic acid. YdfG is apparently supplementing RutE, the presumed malonic semialdehyde reductase involved in pyrimidine degradation since both are able to deto [...]
       0.592
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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