STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rspBPutative zinc-binding dehydrogenase rspb; Not known; probable catabolic enzyme (339 aa)    
Predicted Functional Partners:
rspA
Mandelate racemase/muconate lactonizing enzyme family protein rspa; Probably involved in the degradation of homoserine lactone (HSL) or of a metabolite of HSL that signals starvation
 
 0.985
uxuB
D-mannonate oxidoreductase, nad-dependent; Belongs to the mannitol dehydrogenase family. UxuB subfamily
    
 0.961
uxaC
D-glucoronate/d-galacturonate isomerase; Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family
    
 0.957
lgoD
L-galactonate 5-dehydrogenase; Catalyzes the oxidation of L-galactonate to D-tagaturonate. Required for growth on L-galactonate as the sole carbon source. In vitro, can also use L-gulonate
  
  
 
0.837
araD
L-ribulose-5-phosphate 4-epimerase AraD; Involved in the degradation of L-arabinose . Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D- xylulose 5-phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon- carbon bond cleavage analogous to a class II aldolase reaction)
     
  0.800
sgbE
L-ribulose-5-phosphate 4-epimerase SgbE; Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D-xylulose 5-phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon-carbon bond cleavage analogous to a class II aldolase reaction). May be involved in the utilization of 2,3-diketo-L-gulonate
     
  0.800
ulaF
L-ribulose-5-phosphate 4-epimerase UlaF; Catalyzes the isomerization of L-ribulose 5-phosphate to D- xylulose 5-phosphate. Is involved in the anaerobic L-ascorbate utilization
     
  0.800
ygcW
Putative deoxygluconate dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family
  
 
 0.707
yggP
Putative zinc-binding dehydrogenase yggp; To K.pneumoniae SorE
  
   
 0.680
ygfF
Putative nad(p)-binding oxidoreductase with nad(p)-binding rossmann-fold domain; Uncharacterized oxidoreductase YgfF; Putative oxidoreductase
      
 0.640
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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