STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rspAMandelate racemase/muconate lactonizing enzyme family protein rspa; Probably involved in the degradation of homoserine lactone (HSL) or of a metabolite of HSL that signals starvation (404 aa)    
Predicted Functional Partners:
rspB
Putative zinc-binding dehydrogenase rspb; Not known; probable catabolic enzyme
 
 0.985
uxuB
D-mannonate oxidoreductase, nad-dependent; Belongs to the mannitol dehydrogenase family. UxuB subfamily
 
  
 0.960
kdgK
2-dehydro-3-deoxygluconokinase; Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG)
 
 
 0.930
kduD
Putative 2-keto-3-deoxy-d-gluconate dehydrogenase; Catalyzes the reversible reduction of 2,5-diketo-3- deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto- 3-deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH . To a lesser extent, can also reduce 5-keto- D-gluconate and oxidize D-gluconate and 1,2-propanediol . Together with KduI, seems to play a role in the catabolism of hexuronates under osmotic stress conditions, substituting for the regular hexuronate degrading enzymes UxaABC and UxuAB whose expression is repressed in these con [...]
 
  0.925
uxaA
D-altronate dehydratase; Catalyzes the dehydration of D-altronate
  
 
  0.906
uxuA
D-mannonate dehydratase; Catalyzes the dehydration of D-mannonate
    
 0.863
rspR
Gntr family transcriptional regulator, rspab operon transcriptional repressor; Repressor of the rspAB operon. Acts by binding directly to the upstream region of rspA
 
  
 0.809
rpiB
Allose-6-phosphate isomerase/ribose-5-phosphate isomerase B; Catalyzes the interconversion of ribulose-5-P and ribose-5-P. It probably also has activity on D-allose 6-phosphate
   
 
  0.803
gnd
6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
     
  0.800
rpiA
Ribose 5-phosphate isomerase, constitutive; Involved in the first step of the non-oxidative branch of the pentose phosphate pathway. It catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. Can also act on D-ribose-5- diphosphate and D-ribose-5-triphosphate as substrate
     
  0.800
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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