| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| aaeB | asr | b3240 | b1597 | Aromatic carboxylic acid efflux pump subunit aaeb; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell. Substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate | Acid shock-inducible periplasmic protein; Required for growth and/or survival at acidic conditions (pH 4.5). Needed for the adaptation process at pH 4.5 that enables cells to survive at extremely low pH (pH 2.0) | 0.531 |
| aaeB | flk | b3240 | b2321 | Aromatic carboxylic acid efflux pump subunit aaeb; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell. Substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate | Putative flagella assembly protein; Acts as a regulator of flagellar gene expression by modulating the protein level of the anti sigma factor FlgM upon sensing ring completion or hook elongation. Flk could inhibit FlgM secretion by acting as a braking system for the flagellar-associated type III secretion (T3S) system. Plays a role in hindering to flip the flagellar T3S specificity switch from the rod and hook-type substrates to filament-type substrates prior to hook-basal body (HBB) completion possibly by preventing interaction of FliK with FlhB (By similarity) | 0.726 |
| aaeB | ompX | b3240 | b0814 | Aromatic carboxylic acid efflux pump subunit aaeb; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell. Substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate | Membrane; Outer membrane constituents; Belongs to the Ail/OmpX/PagC/Lom family | 0.754 |
| aaeB | yceK | b3240 | b1050 | Aromatic carboxylic acid efflux pump subunit aaeb; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell. Substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate | DUF1375 domain-containing lipoprotein YceK; To E.coli YidQ | 0.472 |
| aaeB | ygaC | b3240 | b2671 | Aromatic carboxylic acid efflux pump subunit aaeb; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell. Substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate | annotation not available | 0.602 |
| asr | aaeB | b1597 | b3240 | Acid shock-inducible periplasmic protein; Required for growth and/or survival at acidic conditions (pH 4.5). Needed for the adaptation process at pH 4.5 that enables cells to survive at extremely low pH (pH 2.0) | Aromatic carboxylic acid efflux pump subunit aaeb; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell. Substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate | 0.531 |
| asr | flk | b1597 | b2321 | Acid shock-inducible periplasmic protein; Required for growth and/or survival at acidic conditions (pH 4.5). Needed for the adaptation process at pH 4.5 that enables cells to survive at extremely low pH (pH 2.0) | Putative flagella assembly protein; Acts as a regulator of flagellar gene expression by modulating the protein level of the anti sigma factor FlgM upon sensing ring completion or hook elongation. Flk could inhibit FlgM secretion by acting as a braking system for the flagellar-associated type III secretion (T3S) system. Plays a role in hindering to flip the flagellar T3S specificity switch from the rod and hook-type substrates to filament-type substrates prior to hook-basal body (HBB) completion possibly by preventing interaction of FliK with FlhB (By similarity) | 0.731 |
| asr | ompX | b1597 | b0814 | Acid shock-inducible periplasmic protein; Required for growth and/or survival at acidic conditions (pH 4.5). Needed for the adaptation process at pH 4.5 that enables cells to survive at extremely low pH (pH 2.0) | Membrane; Outer membrane constituents; Belongs to the Ail/OmpX/PagC/Lom family | 0.607 |
| asr | phoB | b1597 | b0399 | Acid shock-inducible periplasmic protein; Required for growth and/or survival at acidic conditions (pH 4.5). Needed for the adaptation process at pH 4.5 that enables cells to survive at extremely low pH (pH 2.0) | Two-component system, ompr family, phosphate regulon response regulator phob; This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited | 0.561 |
| asr | rstA | b1597 | b1608 | Acid shock-inducible periplasmic protein; Required for growth and/or survival at acidic conditions (pH 4.5). Needed for the adaptation process at pH 4.5 that enables cells to survive at extremely low pH (pH 2.0) | Two-component system, ompr family, response regulator rsta; Member of the two-component regulatory system RstB/RstA | 0.579 |
| asr | rutA | b1597 | b1012 | Acid shock-inducible periplasmic protein; Required for growth and/or survival at acidic conditions (pH 4.5). Needed for the adaptation process at pH 4.5 that enables cells to survive at extremely low pH (pH 2.0) | Pyrimidine oxygenase, fmn-dependent; Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate. Requires the flavin reductase RutF to regenerate FMN in vivo. RutF can be substituted by Fre in vitro | 0.577 |
| asr | yceK | b1597 | b1050 | Acid shock-inducible periplasmic protein; Required for growth and/or survival at acidic conditions (pH 4.5). Needed for the adaptation process at pH 4.5 that enables cells to survive at extremely low pH (pH 2.0) | DUF1375 domain-containing lipoprotein YceK; To E.coli YidQ | 0.544 |
| asr | yciW | b1597 | b1287 | Acid shock-inducible periplasmic protein; Required for growth and/or survival at acidic conditions (pH 4.5). Needed for the adaptation process at pH 4.5 that enables cells to survive at extremely low pH (pH 2.0) | Uncharacterized protein YciW; Putative enzyme; Not classified | 0.671 |
| asr | ydgU | b1597 | b4601 | Acid shock-inducible periplasmic protein; Required for growth and/or survival at acidic conditions (pH 4.5). Needed for the adaptation process at pH 4.5 that enables cells to survive at extremely low pH (pH 2.0) | annotation not available | 0.584 |
| asr | ygaC | b1597 | b2671 | Acid shock-inducible periplasmic protein; Required for growth and/or survival at acidic conditions (pH 4.5). Needed for the adaptation process at pH 4.5 that enables cells to survive at extremely low pH (pH 2.0) | annotation not available | 0.620 |
| flk | aaeB | b2321 | b3240 | Putative flagella assembly protein; Acts as a regulator of flagellar gene expression by modulating the protein level of the anti sigma factor FlgM upon sensing ring completion or hook elongation. Flk could inhibit FlgM secretion by acting as a braking system for the flagellar-associated type III secretion (T3S) system. Plays a role in hindering to flip the flagellar T3S specificity switch from the rod and hook-type substrates to filament-type substrates prior to hook-basal body (HBB) completion possibly by preventing interaction of FliK with FlhB (By similarity) | Aromatic carboxylic acid efflux pump subunit aaeb; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell. Substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate | 0.726 |
| flk | asr | b2321 | b1597 | Putative flagella assembly protein; Acts as a regulator of flagellar gene expression by modulating the protein level of the anti sigma factor FlgM upon sensing ring completion or hook elongation. Flk could inhibit FlgM secretion by acting as a braking system for the flagellar-associated type III secretion (T3S) system. Plays a role in hindering to flip the flagellar T3S specificity switch from the rod and hook-type substrates to filament-type substrates prior to hook-basal body (HBB) completion possibly by preventing interaction of FliK with FlhB (By similarity) | Acid shock-inducible periplasmic protein; Required for growth and/or survival at acidic conditions (pH 4.5). Needed for the adaptation process at pH 4.5 that enables cells to survive at extremely low pH (pH 2.0) | 0.731 |
| flk | ompX | b2321 | b0814 | Putative flagella assembly protein; Acts as a regulator of flagellar gene expression by modulating the protein level of the anti sigma factor FlgM upon sensing ring completion or hook elongation. Flk could inhibit FlgM secretion by acting as a braking system for the flagellar-associated type III secretion (T3S) system. Plays a role in hindering to flip the flagellar T3S specificity switch from the rod and hook-type substrates to filament-type substrates prior to hook-basal body (HBB) completion possibly by preventing interaction of FliK with FlhB (By similarity) | Membrane; Outer membrane constituents; Belongs to the Ail/OmpX/PagC/Lom family | 0.739 |
| flk | yciW | b2321 | b1287 | Putative flagella assembly protein; Acts as a regulator of flagellar gene expression by modulating the protein level of the anti sigma factor FlgM upon sensing ring completion or hook elongation. Flk could inhibit FlgM secretion by acting as a braking system for the flagellar-associated type III secretion (T3S) system. Plays a role in hindering to flip the flagellar T3S specificity switch from the rod and hook-type substrates to filament-type substrates prior to hook-basal body (HBB) completion possibly by preventing interaction of FliK with FlhB (By similarity) | Uncharacterized protein YciW; Putative enzyme; Not classified | 0.748 |
| flk | ygaC | b2321 | b2671 | Putative flagella assembly protein; Acts as a regulator of flagellar gene expression by modulating the protein level of the anti sigma factor FlgM upon sensing ring completion or hook elongation. Flk could inhibit FlgM secretion by acting as a braking system for the flagellar-associated type III secretion (T3S) system. Plays a role in hindering to flip the flagellar T3S specificity switch from the rod and hook-type substrates to filament-type substrates prior to hook-basal body (HBB) completion possibly by preventing interaction of FliK with FlhB (By similarity) | annotation not available | 0.563 |
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