STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fumAFumarate hydratase (fumarase a), aerobic class i; Catalyzes the reversible hydration of fumarate to (S)-malate. Functions as an aerobic enzyme in the direction of malate formation as part of the citric acid cycle. Accounts for about 80% of the fumarase activity when the bacteria grow aerobically. To a lesser extent, also displays D-tartrate dehydratase activity in vitro, but is not able to convert (R)-malate, L-tartrate or meso-tartrate. Can also catalyze the isomerization of enol- to keto-oxaloacetate (548 aa)    
Predicted Functional Partners:
fumC
Fumarate hydratase (fumarase c),aerobic class ii; Involved in the TCA cycle. FumC seems to be a backup enzyme for FumA under conditions of iron limitation and oxidative stress . Catalyzes the stereospecific interconversion of fumarate to L-malate
  
 
 0.997
sdhC
Succinate dehydrogenase / fumarate reductase, cytochrome b subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH)
  
 
 0.996
sdhA
Succinate dehydrogenase / fumarate reductase, flavoprotein subunit; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth
  
 
 0.995
sdhB
Succinate:quinone oxidoreductase, iron-sulfur cluster binding protein; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth
  
 
 0.992
sdhD
Succinate dehydrogenase / fumarate reductase, membrane anchor subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH)
  
 
 0.989
mdh
Malate dehydrogenase, nad(p)-binding; Catalyzes the reversible oxidation of malate to oxaloacetate
  
 
 0.988
gltA
Belongs to the citrate synthase family
  
 
 0.977
frdA
Anaerobic fumarate reductase catalytic and nad/flavoprotein subunit; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth
  
 
 0.976
maeB
Malate dehydrogenase (oxaloacetate-decarboxylating)(nadp+); In the N-terminal section; belongs to the malic enzymes family
 
 
 0.975
maeA
Malate dehydrogenase, decarboxylating, nad-requiring; NAD-linked malate dehydrogenase (malic enzyme); Protein involved in gluconeogenesis
  
 
 0.962
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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