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tyrS protein (Escherichia coli K12 MG1655) - STRING interaction network
"tyrS" - Tyrosine--tRNA ligase in Escherichia coli K12 MG1655
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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tyrSTyrosine--tRNA ligase; Catalyzes the attachment of L-tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr). Also mischarges tRNA(Tyr) with D-tyrosine, although Vmax is much lower (424 aa)    
Predicted Functional Partners:
metG
Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily (677 aa)
   
 
  0.948
pheT
Phenylalanine tRNA synthetase, beta-subunit; Protein involved in tRNA aminoacylation for protein translation (795 aa)
   
 
  0.948
thrS
Threonine--tRNA ligase; Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction- L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). The rate- limiting step is amino acid activation in the presence of tRNA. The 2’-OH of the acceptor base (adenine 76, A76) of tRNA(Thr) and His-309 collaborate to transfer L-Thr to the tRNA; substitution of 2’-OH of A76 with hydrogen or fluorine decreases transfer efficiency 760 and 100-fold respectively. The zinc ion in the active site discriminates against charging of the isoster [...] (642 aa)
   
 
  0.885
serS
Serine--tRNA ligase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (430 aa)
   
   
  0.875
pheS
Phenylalanine tRNA synthetase, alpha-subunit; Protein involved in tRNA aminoacylation for protein translation (327 aa)
   
 
  0.870
pdxH
Pyridoxine/pyridoxamine 5’-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5’- phosphate (PNP) or pyridoxamine 5’-phosphate (PMP) into pyridoxal 5’-phosphate (PLP) (218 aa)
   
   
  0.840
leuS
Leucine--tRNA ligase; Leucine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation; Belongs to the class-I aminoacyl-tRNA synthetase family (860 aa)
   
   
  0.830
hisS
Histidine--tRNA ligase; Histidine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation (424 aa)
   
   
  0.826
cysS
Cysteine--tRNA ligase; Cysteine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation; Belongs to the class-I aminoacyl-tRNA synthetase family (461 aa)
     
 
  0.820
argS
Arginine--tRNA ligase; Arginine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation (577 aa)
 
 
  0.807
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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