node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
appA | bluF | b0980 | b1163 | Phosphoanhydride phosphorylase; pH 2.5 acid phosphatase; periplasmic; Protein involved in phosphorus metabolic process and response to starvation. | Anti-repressor for YcgE, blue light-responsive; Binds to and releases the BluR repressor from its bound DNA target in a blue light-dependent (470 nm) fashion. A shift to low temperature also triggers a BluF-mediated relief of repression by BluR, suggesting BluF may serve as a thermometer. Blue light may act to increase the affinity of BluF for BluR, allowing it to be released from its operator. The protein has a reversible photocycle, and undergoes structural changes, probably in the EAL domain, in response to light. | 0.594 |
appA | bluR | b0980 | b1162 | Phosphoanhydride phosphorylase; pH 2.5 acid phosphatase; periplasmic; Protein involved in phosphorus metabolic process and response to starvation. | Repressor of blue light-responsive genes; Controls the expression of several small proteins that may play a role in biofilm maturation. Binds to and represses the operator of the ycgZ-ymgA-ariR-ymgC operon and also regulates ynaK. Binding is antagonized by BluF upon blue light (470 nm) irradiation. Blue light may increase the affinity of BluF for BluR, allowing it to be released from its operator. | 0.621 |
appA | ppsR | b0980 | b1703 | Phosphoanhydride phosphorylase; pH 2.5 acid phosphatase; periplasmic; Protein involved in phosphorus metabolic process and response to starvation. | PEP synthase kinase and PEP synthase pyrophosphorylase; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. | 0.955 |
appA | yfaL | b0980 | b2233 | Phosphoanhydride phosphorylase; pH 2.5 acid phosphatase; periplasmic; Protein involved in phosphorus metabolic process and response to starvation. | Adhesin; Probably an autotransporter. | 0.642 |
aroH | ppsA | b1704 | b1702 | 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan repressible; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. | 0.844 |
aroH | ppsR | b1704 | b1703 | 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan repressible; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | PEP synthase kinase and PEP synthase pyrophosphorylase; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. | 0.622 |
aroH | ydiE | b1704 | b1705 | 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan repressible; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | Hemin uptake protein HemP homolog; To Y.enterocolitica HemP. | 0.497 |
bluF | appA | b1163 | b0980 | Anti-repressor for YcgE, blue light-responsive; Binds to and releases the BluR repressor from its bound DNA target in a blue light-dependent (470 nm) fashion. A shift to low temperature also triggers a BluF-mediated relief of repression by BluR, suggesting BluF may serve as a thermometer. Blue light may act to increase the affinity of BluF for BluR, allowing it to be released from its operator. The protein has a reversible photocycle, and undergoes structural changes, probably in the EAL domain, in response to light. | Phosphoanhydride phosphorylase; pH 2.5 acid phosphatase; periplasmic; Protein involved in phosphorus metabolic process and response to starvation. | 0.594 |
bluF | bluR | b1163 | b1162 | Anti-repressor for YcgE, blue light-responsive; Binds to and releases the BluR repressor from its bound DNA target in a blue light-dependent (470 nm) fashion. A shift to low temperature also triggers a BluF-mediated relief of repression by BluR, suggesting BluF may serve as a thermometer. Blue light may act to increase the affinity of BluF for BluR, allowing it to be released from its operator. The protein has a reversible photocycle, and undergoes structural changes, probably in the EAL domain, in response to light. | Repressor of blue light-responsive genes; Controls the expression of several small proteins that may play a role in biofilm maturation. Binds to and represses the operator of the ycgZ-ymgA-ariR-ymgC operon and also regulates ynaK. Binding is antagonized by BluF upon blue light (470 nm) irradiation. Blue light may increase the affinity of BluF for BluR, allowing it to be released from its operator. | 0.997 |
bluF | ppsR | b1163 | b1703 | Anti-repressor for YcgE, blue light-responsive; Binds to and releases the BluR repressor from its bound DNA target in a blue light-dependent (470 nm) fashion. A shift to low temperature also triggers a BluF-mediated relief of repression by BluR, suggesting BluF may serve as a thermometer. Blue light may act to increase the affinity of BluF for BluR, allowing it to be released from its operator. The protein has a reversible photocycle, and undergoes structural changes, probably in the EAL domain, in response to light. | PEP synthase kinase and PEP synthase pyrophosphorylase; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. | 0.645 |
bluR | appA | b1162 | b0980 | Repressor of blue light-responsive genes; Controls the expression of several small proteins that may play a role in biofilm maturation. Binds to and represses the operator of the ycgZ-ymgA-ariR-ymgC operon and also regulates ynaK. Binding is antagonized by BluF upon blue light (470 nm) irradiation. Blue light may increase the affinity of BluF for BluR, allowing it to be released from its operator. | Phosphoanhydride phosphorylase; pH 2.5 acid phosphatase; periplasmic; Protein involved in phosphorus metabolic process and response to starvation. | 0.621 |
bluR | bluF | b1162 | b1163 | Repressor of blue light-responsive genes; Controls the expression of several small proteins that may play a role in biofilm maturation. Binds to and represses the operator of the ycgZ-ymgA-ariR-ymgC operon and also regulates ynaK. Binding is antagonized by BluF upon blue light (470 nm) irradiation. Blue light may increase the affinity of BluF for BluR, allowing it to be released from its operator. | Anti-repressor for YcgE, blue light-responsive; Binds to and releases the BluR repressor from its bound DNA target in a blue light-dependent (470 nm) fashion. A shift to low temperature also triggers a BluF-mediated relief of repression by BluR, suggesting BluF may serve as a thermometer. Blue light may act to increase the affinity of BluF for BluR, allowing it to be released from its operator. The protein has a reversible photocycle, and undergoes structural changes, probably in the EAL domain, in response to light. | 0.997 |
bluR | ppsR | b1162 | b1703 | Repressor of blue light-responsive genes; Controls the expression of several small proteins that may play a role in biofilm maturation. Binds to and represses the operator of the ycgZ-ymgA-ariR-ymgC operon and also regulates ynaK. Binding is antagonized by BluF upon blue light (470 nm) irradiation. Blue light may increase the affinity of BluF for BluR, allowing it to be released from its operator. | PEP synthase kinase and PEP synthase pyrophosphorylase; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. | 0.628 |
gspB | ppsR | b3322 | b1703 | Part of gsp divergon involved in type II protein secretion; Part of a cryptic operon that encodes proteins involved in type II secretion pathway in other organisms, but is not expressed in strain K12 under standard laboratory conditions. May play a regulatory role under conditions of derepressed gsp gene expression. | PEP synthase kinase and PEP synthase pyrophosphorylase; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. | 0.902 |
gspB | yfaL | b3322 | b2233 | Part of gsp divergon involved in type II protein secretion; Part of a cryptic operon that encodes proteins involved in type II secretion pathway in other organisms, but is not expressed in strain K12 under standard laboratory conditions. May play a regulatory role under conditions of derepressed gsp gene expression. | Adhesin; Probably an autotransporter. | 0.810 |
kdsD | ppsA | b3197 | b1702 | D-arabinose 5-phosphate isomerase; Involved in the biosynthesis of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs). KdsD is not essential in the KDO biosynthesis and can be substituted by GutQ. Catalyzes the reversible aldol-ketol isomerization between D- ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P). | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. | 0.452 |
kdsD | ppsR | b3197 | b1703 | D-arabinose 5-phosphate isomerase; Involved in the biosynthesis of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs). KdsD is not essential in the KDO biosynthesis and can be substituted by GutQ. Catalyzes the reversible aldol-ketol isomerization between D- ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P). | PEP synthase kinase and PEP synthase pyrophosphorylase; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. | 0.798 |
ppsA | aroH | b1702 | b1704 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. | 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan repressible; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | 0.844 |
ppsA | kdsD | b1702 | b3197 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. | D-arabinose 5-phosphate isomerase; Involved in the biosynthesis of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs). KdsD is not essential in the KDO biosynthesis and can be substituted by GutQ. Catalyzes the reversible aldol-ketol isomerization between D- ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P). | 0.452 |
ppsA | ppsR | b1702 | b1703 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. | PEP synthase kinase and PEP synthase pyrophosphorylase; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. | 0.976 |