STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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chbRArac family transcriptional regulator, dual regulator of chb operon; Dual-function repressor/activator of the chbBCARFG operon. In the absence of the inducing sugar chitobiose, together with NagC, represses the chbBCARFG operon for the uptake and metabolism of chitobiose. In association with Crp, and probably in the presence of chitobiose 6-phosphate, induces the transcription of the chbBCARFG operon (280 aa)    
Predicted Functional Partners:
chbC
N,n'-diacetylchitobiose-specific enzyme iic component of pts; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ChbABC PTS system is involved in the transport of the chitin disaccharide N,N'-diacetylchitobiose (GlcNAc2) . Also able to use N,N',N''-triacetyl chitotriose (GlcNAc3)
  
 0.997
chbF
Monoacetylchitobiose-6-phosphate hydrolase; Hydrolyzes a wide variety of P-beta-glucosides including cellobiose-6P, salicin-6P, arbutin-6P, gentiobiose-6P, methyl-beta- glucoside-6P and p-nitrophenyl-beta-D-glucopyranoside-6P. Is also able to hydrolyze phospho-N,N'-diacetylchitobiose
  
 0.993
chbA
N,n'-diacetylchitobiose-specific enzyme iia component of pts; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ChbABC PTS system is involved in the transport of the chitin disaccharide N,N'-diacetylchitobiose (GlcNAc2) Also able to use N,N',N''-triacetyl chitotriose (GlcNAc3)
 
  
 0.993
chbB
N,n'-diacetylchitobiose-specific enzyme iib component of pts; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ChbABC PTS system is involved in the transport of the chitin disaccharide N,N'-diacetylchitobiose (GlcNAc2) . Also able to use N,N',N''-triacetyl chitotriose (GlcNAc3)
  
 0.988
chbG
Chito-oligosaccharide deacetylase; ChbG is essential for growth on the acetylated chitooligosaccharides chitobiose and chitotriose but is dispensable for growth on cellobiose and chitosan dimer, the deacetylated form of chitobiose. Deacetylation of chitobiose-6-P and chitotriose-6-P is necessary for both the activation of the chb promoter by the regulatory protein ChbR and the hydrolysis of phosphorylated beta-glucosides by the phospho-beta-glucosidase ChbF. Catalyzes the removal of only one acetyl group from chitobiose-6-P to yield monoacetylchitobiose-6-P, the inducer of ChbR and the [...]
 
  
 0.984
nagC
N-acetylglucosamine-inducible nag divergent operon transcriptional repressor; Acts as a repressor of the nagEBACD operon and acts both as an activator and a repressor for the transcription of the glmSU operon
     
 0.834
bcsZ
Endo-1,4-D-glucanase; Hydrolyzes carboxymethylcellulose
      
 0.821
araC
Arac family transcriptional regulator, arabinose operon regulatory protein; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose Functions both as a positive and a negative regulator . In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters In the absence of arabinose, negatively regulates the araBAD operon . Represses its own transcription . Acts by binding directly to DNA
   
 
 0.782
rhaR
Arac family transcriptional regulator, l-rhamnose operon transcriptional activator rhar; Activates expression of the rhaSR operon in response to L- rhamnose
   
 
 0.746
ascB
Cryptic 6-phospho-beta-glucosidase; Can hydrolyze salicin, cellobiose, and probably arbutin
     
 0.739
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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