STRING protein interaction network
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
Your Input:
Gene Fusion
dmlRLysr family transcriptional regulator, transcriptional activator for dmla; Transcriptional regulator required for the aerobic growth on D-malate as the sole carbon source. Induces the expression of dmlA in response to D-malate or L- or meso-tartrate. Negatively regulates its own expression (307 aa)    
Predicted Functional Partners:
Tartrate dehydrogenase/decarboxylase / d-malate dehydrogenase; Catalyzes the NAD(+)-dependent oxidative decarboxylation of D-malate into pyruvate. Is essential for aerobic growth on D-malate as the sole carbon source. But is not required for anaerobic D-malate utilization, although DmlA is expressed and active in those conditions. Appears to be not able to use L-tartrate as a substrate for dehydrogenation instead of D-malate
Uncharacterized HTH-type transcriptional regulator YijO; Putative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription
Fructosamine kinase family protein; Ketoamine kinase that phosphorylates ketoamines on the third carbon of the sugar moiety to generate ketoamine 3-phosphate (By similarity). Its precise substrate are unknown: does not have ribulosamine and/or erythrulosamine 3-kinase activity in vitro
Arginine n-succinyltransferase; Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine
Cell division activator; Activates the cell division inhibited by chromosomal DNA over-replication
Putative yeawx dioxygenase alpha subunit; Converts carnitine to trimethylamine and malic semialdehyde. Can also use gamma-butyrobetaine, choline and betaine as substrates
Betaine/carnitine transporter, bcct family; Probable transporter whose substrate is unknown. Is not involved in aerobic D-malate transport
Leucine efflux protein; Exporter of leucine. Can also transport its natural analog L- alpha-amino-n-butyric acid and some other structurally unrelated amino acids
Two-component system, citb family, sensor histidine kinase dcus; Member of the two-component regulatory system DcuR/DcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN; dcuB; dcuC; sdhCDAB; etc.). Weakly regulates the aerobic C4- dicarboxylate transporter dctA. Activates DcuR by phosphorylation
Putative yeawx dioxygenase beta subunit, reductase component; Converts carnitine to trimethylamine and malic semialdehyde. Can also use gamma-butyrobetaine, choline and betaine as substrates
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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