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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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[Homology]
Score
dmlACatalyzes the NAD(+)-dependent oxidative decarboxylation of D-malate into pyruvate. Is essential for aerobic growth on D-malate as the sole carbon source. But is not required for anaerobic D-malate utilization, although DmlA is expressed and active in those conditions. Appears to be not able to use L-tartrate as a substrate for dehydrogenation instead of D-malate (361 aa)    
Predicted Functional Partners:
ilvI
Acetolactate synthase III, valine sensitive, large subunit
 
 0.950
ilvB
Acetolactate synthase I,valine-sensitive, large subunit; Belongs to the TPP enzyme family
 
 0.949
ilvH
Belongs to the acetolactate synthase small subunit family.
 
 
 0.947
leuC
Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate
 
 0.932
ilvN
Belongs to the acetolactate synthase small subunit family.
  
 
 0.923
pfo
Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
  
 
 0.913
ttdA
L-tartrate dehydratase, subunit A; Protein involved in fermentation
 
  
 0.913
ilvM
Pseudogene, acetolactate synthase 2 large subunit, valine-insensitive; acetolactate synthase II, large subunit, cryptic, interrupted
  
 
  0.907
ttdB
L-tartrate dehydratase, subunit B; Protein involved in fermentation
  
 
 0.903
ybiW
Probably shows dehydratase activity.
     
 0.901
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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