node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
alx | mntP | b3088 | b1821 | Putative membrane-bound redox modulator alx; Has been proposed to be a redox modulator | Putative mn(2+) efflux pump, mntr-regulated; Probably functions as a manganese efflux pump | 0.708 |
apaG | htpX | b0050 | b1829 | annotation not available | Zinc dependent endoprotease; Membrane-localized protease able to endoproteolytically degrade overproduced SecY but not YccA, another membrane protein. It seems to cleave SecY at specific cytoplasmic sites. Does not require ATP. Its natural substrate has not been identified. Probably plays a role in the quality control of integral membrane proteins | 0.542 |
apaG | mntP | b0050 | b1821 | annotation not available | Putative mn(2+) efflux pump, mntr-regulated; Probably functions as a manganese efflux pump | 0.638 |
apaG | proP | b0050 | b4111 | annotation not available | Mfs transporter, mhs family, proline/betaine transporter; Proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response | 0.531 |
htpX | apaG | b1829 | b0050 | Zinc dependent endoprotease; Membrane-localized protease able to endoproteolytically degrade overproduced SecY but not YccA, another membrane protein. It seems to cleave SecY at specific cytoplasmic sites. Does not require ATP. Its natural substrate has not been identified. Probably plays a role in the quality control of integral membrane proteins | annotation not available | 0.542 |
htpX | mntP | b1829 | b1821 | Zinc dependent endoprotease; Membrane-localized protease able to endoproteolytically degrade overproduced SecY but not YccA, another membrane protein. It seems to cleave SecY at specific cytoplasmic sites. Does not require ATP. Its natural substrate has not been identified. Probably plays a role in the quality control of integral membrane proteins | Putative mn(2+) efflux pump, mntr-regulated; Probably functions as a manganese efflux pump | 0.536 |
manZ | mntP | b1819 | b1821 | Mannose-specific enzyme iid component of pts; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane . The enzyme II ManXYZ PTS system is involved in mannose transport . Also functions as a receptor for bacterial chemotaxis and is required for infection of the cell by bacteriophage lambda where it most likely functions as a pore for penetration of lambda DNA | Putative mn(2+) efflux pump, mntr-regulated; Probably functions as a manganese efflux pump | 0.615 |
mntH | mntP | b2392 | b1821 | Mn(2(+))/Fe(2(+)): H(+) symporter MntH; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake. Can also transport cadmium, cobalt, zinc and to a lesser extent nickel and copper. Involved in response to reactive oxygen | Putative mn(2+) efflux pump, mntr-regulated; Probably functions as a manganese efflux pump | 0.891 |
mntH | mntR | b2392 | b0817 | Mn(2(+))/Fe(2(+)): H(+) symporter MntH; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake. Can also transport cadmium, cobalt, zinc and to a lesser extent nickel and copper. Involved in response to reactive oxygen | Dtxr family transcriptional regulator, manganese transport regulator; In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP | 0.963 |
mntH | mntS | b2392 | b4705 | Mn(2(+))/Fe(2(+)): H(+) symporter MntH; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake. Can also transport cadmium, cobalt, zinc and to a lesser extent nickel and copper. Involved in response to reactive oxygen | Mn(2)-response protein, MntR-repressed; Required for repression of mntH by MntR. May function as a chaperone that makes manganese more available by delivering it to the necessary cellular locations when manganese is limiting | 0.732 |
mntH | zitB | b2392 | b0752 | Mn(2(+))/Fe(2(+)): H(+) symporter MntH; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake. Can also transport cadmium, cobalt, zinc and to a lesser extent nickel and copper. Involved in response to reactive oxygen | Zn(2(+))/Cd(2(+))/Ni(2(+))/Cu(2(+)) exporter; Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc, whereas ZntA is required for growth at more toxic concentrations | 0.503 |
mntP | alx | b1821 | b3088 | Putative mn(2+) efflux pump, mntr-regulated; Probably functions as a manganese efflux pump | Putative membrane-bound redox modulator alx; Has been proposed to be a redox modulator | 0.708 |
mntP | apaG | b1821 | b0050 | Putative mn(2+) efflux pump, mntr-regulated; Probably functions as a manganese efflux pump | annotation not available | 0.638 |
mntP | htpX | b1821 | b1829 | Putative mn(2+) efflux pump, mntr-regulated; Probably functions as a manganese efflux pump | Zinc dependent endoprotease; Membrane-localized protease able to endoproteolytically degrade overproduced SecY but not YccA, another membrane protein. It seems to cleave SecY at specific cytoplasmic sites. Does not require ATP. Its natural substrate has not been identified. Probably plays a role in the quality control of integral membrane proteins | 0.536 |
mntP | manZ | b1821 | b1819 | Putative mn(2+) efflux pump, mntr-regulated; Probably functions as a manganese efflux pump | Mannose-specific enzyme iid component of pts; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane . The enzyme II ManXYZ PTS system is involved in mannose transport . Also functions as a receptor for bacterial chemotaxis and is required for infection of the cell by bacteriophage lambda where it most likely functions as a pore for penetration of lambda DNA | 0.615 |
mntP | mntH | b1821 | b2392 | Putative mn(2+) efflux pump, mntr-regulated; Probably functions as a manganese efflux pump | Mn(2(+))/Fe(2(+)): H(+) symporter MntH; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake. Can also transport cadmium, cobalt, zinc and to a lesser extent nickel and copper. Involved in response to reactive oxygen | 0.891 |
mntP | mntR | b1821 | b0817 | Putative mn(2+) efflux pump, mntr-regulated; Probably functions as a manganese efflux pump | Dtxr family transcriptional regulator, manganese transport regulator; In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP | 0.930 |
mntP | mntS | b1821 | b4705 | Putative mn(2+) efflux pump, mntr-regulated; Probably functions as a manganese efflux pump | Mn(2)-response protein, MntR-repressed; Required for repression of mntH by MntR. May function as a chaperone that makes manganese more available by delivering it to the necessary cellular locations when manganese is limiting | 0.888 |
mntP | proP | b1821 | b4111 | Putative mn(2+) efflux pump, mntr-regulated; Probably functions as a manganese efflux pump | Mfs transporter, mhs family, proline/betaine transporter; Proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response | 0.526 |
mntP | ygeR | b1821 | b2865 | Putative mn(2+) efflux pump, mntr-regulated; Probably functions as a manganese efflux pump | Lysm domain-containing putative peptidase lipoprotein yger; Belongs to the peptidase M23B family | 0.511 |