STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mntPPutative mn(2+) efflux pump, mntr-regulated; Probably functions as a manganese efflux pump (188 aa)    
Predicted Functional Partners:
mntR
Dtxr family transcriptional regulator, manganese transport regulator; In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP
 
   
 0.930
mntH
Mn(2(+))/Fe(2(+)): H(+) symporter MntH; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake. Can also transport cadmium, cobalt, zinc and to a lesser extent nickel and copper. Involved in response to reactive oxygen
      
 0.891
mntS
Mn(2)-response protein, MntR-repressed; Required for repression of mntH by MntR. May function as a chaperone that makes manganese more available by delivering it to the necessary cellular locations when manganese is limiting
      
 0.888
alx
Putative membrane-bound redox modulator alx; Has been proposed to be a redox modulator
      
 0.708
apaG
annotation not available
      
 0.638
manZ
Mannose-specific enzyme iid component of pts; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane . The enzyme II ManXYZ PTS system is involved in mannose transport . Also functions as a receptor for bacterial chemotaxis and is required for infection of the cell by bacteriophage lambda where it most likely functions as a pore for penetration of lambda DNA
      0.615
zitB
Zn(2(+))/Cd(2(+))/Ni(2(+))/Cu(2(+)) exporter; Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc, whereas ZntA is required for growth at more toxic concentrations
     
 0.602
htpX
Zinc dependent endoprotease; Membrane-localized protease able to endoproteolytically degrade overproduced SecY but not YccA, another membrane protein. It seems to cleave SecY at specific cytoplasmic sites. Does not require ATP. Its natural substrate has not been identified. Probably plays a role in the quality control of integral membrane proteins
      
 0.536
proP
Mfs transporter, mhs family, proline/betaine transporter; Proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response
      
 0.526
ygeR
Lysm domain-containing putative peptidase lipoprotein yger; Belongs to the peptidase M23B family
      
 0.511
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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