STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yebKRepresses the expression of the hex regulon (zwf, eda, glp and gap) (289 aa)    
Predicted Functional Partners:
eda
Involved in the degradation of glucose via the Entner- Doudoroff pathway. Catalyzes the reversible, stereospecific retro-aldol cleavage of 2-Keto-3-deoxy-6-phosphogluconate (KDPG) to pyruvate and D- glyceraldehyde-3-phosphate. In the synthetic direction, it catalyzes the addition of pyruvate to electrophilic aldehydes with si-facial selectivity. It accepts some nucleophiles other than pyruvate, including 2-oxobutanoate, phenylpyruvate, and fluorobutanoate. It has a preference for the S-configuration at C2 of the electrophile.
 
  
 0.923
edd
Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate. Rule:MF_02094, ECO:0000269|PubMed:17102132,
 
  
 0.908
zwf
Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
  
  
 0.873
glk
Not highly important in E.coli as glucose is transported into the cell by the PTS system already as glucose 6-phosphate
 
  
 0.835
gntR
Negative regulator for the gluconate utilization system GNT- I, the gntUKR operon
   
  
 0.760
gltS
Catalyzes the sodium-dependent, binding-protein-independent transport of glutamate. ECO:0000269|PubMed:2537813, ECO:0000269|PubMed:336628,
      
 0.743
gtrS
Uncharacterized protein YfdI; Putative ligase
      
 0.733
pykA
Pyruvate kinase II, glucose stimulated; Protein involved in glycolysis, fermentation and anaerobic respiration
  
  
 0.645
yidZ
Involved in anaerobic NO protection
      
 0.641
cra
Global transcriptional regulator, which plays an important role in the regulation of carbon metabolism. Activates transcription of genes encoding biosynthetic and oxidative enzymes (involved in Krebs cycle, glyoxylate shunt and gluconeogenesis, such as ppsA and fbp). Represses genes involved in sugar catabolism, such as fruB, pfkA, pykF and adhE. Binds asymmetrically to the two half-sites of its operator. ECO:0000269|PubMed:8230205, ECO:0000269|PubMed:8550429, ECO:0000269|PubMed:8577250, ECO:0000269|PubMed:8858581,
  
   
 0.526
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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