STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
uspCUniversal stress protein c; Required for resistance to DNA-damaging agents (142 aa)    
Predicted Functional Partners:
uspE
Universal stress protein with a role cellular motility; Required for resistance to DNA-damaging agents
   
  
 0.894
uspG
Universal stress protein up12; Has intrinsic autoadenylation and autophosphorylation activities, probably on Ser or Thr residues
      
 0.888
uspF
Nucleotide binding filament protein; Universal stress protein F; Pseudogene, prophage Rac integration site ttcA duplication;Phage or Prophage Related
      
 0.877
kdpD
Fused sensory histidine kinase in two-component regulatory system with kdpe: signal sensing protein; Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates KdpE in response to environmental signals
   
  
 0.849
mukB
Chromosome condensin mukbef, atpase and dna-binding subunit; Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organizes and compacts chromosomes. May achieve or facilitate chromosome segregation by condensation of DNA from both sides of a centrally located replisome during cell division. Stimulates both DNA relaxation and to a lesser extent decatenation activity of topoisomerase IV
  
     0.698
mukE
Chromosome condensin mukbef, muke localization factor; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
  
     0.693
sxy
Dna transformation protein and related proteins; Induces low levels of natural DNA uptake by inducing transcription of the competence genes (the CRP-S regulon) required for DNA transformation. Induction of the CRP-S regulon also requires Sxy- activated promoter (CRP-S), cAMP receptor protein (CRP) and cAMP . Induces CRP-S site-containing genes which are involved in genome maintenance and transcription or encoding transposases and toxin-antitoxin pairs
  
     0.658
mukF
Chromosome condensin mukbef, kleisin-like subunit, binds calcium; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
  
     0.650
cspH
Stress protein, member of the cspa-family; Cold shock-like protein; Protein involved in response to temperature stimulus
  
   
 0.650
ppdA
Putative prepilin peptidase-dependent protein; Not yet known
  
    0.625
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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