STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
zinTMay function as a periplasmic zinc chaperone or mediate direct transport of zinc from the periplasm to the cytoplasm under zinc-limited conditions. Binds zinc with high affinity, and can also bind cadmium, mercury or nickel. Preferentially binds Zn(2+) over Cd(2+). Contains one high affinity metal binding site, and can bind additional metal ions at other sites (216 aa)    
Predicted Functional Partners:
znuA
Zn(2(+)) ABC transporter periplasmic binding protein; Involved in the high-affinity zinc uptake transport system
 
 
 0.997
ykgM
annotation not available
  
  
 0.974
znuC
Zn(2(+)) ABC transporter ATP binding subunit; Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system
  
  
 0.906
zupT
Heavy metal divalent cation transporter zupt; Mediates zinc uptake. May also transport other divalent cations such as copper and cadmium ions
  
   
 0.895
znuB
Zn(2(+)) ABC transporter membrane subunit; Involved in the high-affinity zinc uptake transport system
  
  
 0.864
pliG
Periplasmic inhibitor of g-type lysozyme; Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium
   
  
 0.842
ygfM
annotation not available
      
 0.676
zntR
Merr family transcriptional regulator, zn(ii)-responsive regulator of znta; Zinc-responsive transcriptional regulator of zntA
  
   
 0.646
yeiB
DUF418 family putative inner membrane protein; Involved in transport
      
 0.607
purL
Phosphoribosylformyl-glycineamide synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate
      
 0.579
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
Server load: low (14%) [HD]