| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| amn | shiA | b1982 | b1981 | Amp nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations | Mfs transporter, mhs family, shikimate and dehydroshikimate transport protein; Shikimate transporter; Pseudogene, glycosyltransferase homology | 0.687 |
| aroE | aroG | b3281 | b0754 | Dehydroshikimate reductase, nad(p)-binding; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). It displays no activity in the presence of NAD | 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, phenylalanine repressible; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP) | 0.889 |
| aroE | shiA | b3281 | b1981 | Dehydroshikimate reductase, nad(p)-binding; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). It displays no activity in the presence of NAD | Mfs transporter, mhs family, shikimate and dehydroshikimate transport protein; Shikimate transporter; Pseudogene, glycosyltransferase homology | 0.450 |
| aroG | aroE | b0754 | b3281 | 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, phenylalanine repressible; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP) | Dehydroshikimate reductase, nad(p)-binding; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). It displays no activity in the presence of NAD | 0.889 |
| aroG | shiA | b0754 | b1981 | 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, phenylalanine repressible; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP) | Mfs transporter, mhs family, shikimate and dehydroshikimate transport protein; Shikimate transporter; Pseudogene, glycosyltransferase homology | 0.479 |
| cirA | hfq | b2155 | b4172 | Not yet known. Postulated to participate in iron transport. Outer membrane receptor for colicins IA and IB | Rna-binding protein hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Involved in the regulation of stress responses mediated by the sigma factors RpoS, sigma-E and sigma-32 . Binds with high specificity to tRNAs . Binds sRNA antitoxin RalA . In vitro, stimulates synthesis of long tails by poly(A) polymerase I . Required for RNA phage Qbeta replication . Seems to play a role in persister cell formation; upon overexpression decreas [...] | 0.515 |
| cirA | shiA | b2155 | b1981 | Not yet known. Postulated to participate in iron transport. Outer membrane receptor for colicins IA and IB | Mfs transporter, mhs family, shikimate and dehydroshikimate transport protein; Shikimate transporter; Pseudogene, glycosyltransferase homology | 0.515 |
| cysE | shiA | b3607 | b1981 | Serine o-acetyltransferase; Belongs to the transferase hexapeptide repeat family | Mfs transporter, mhs family, shikimate and dehydroshikimate transport protein; Shikimate transporter; Pseudogene, glycosyltransferase homology | 0.481 |
| hfq | cirA | b4172 | b2155 | Rna-binding protein hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Involved in the regulation of stress responses mediated by the sigma factors RpoS, sigma-E and sigma-32 . Binds with high specificity to tRNAs . Binds sRNA antitoxin RalA . In vitro, stimulates synthesis of long tails by poly(A) polymerase I . Required for RNA phage Qbeta replication . Seems to play a role in persister cell formation; upon overexpression decreas [...] | Not yet known. Postulated to participate in iron transport. Outer membrane receptor for colicins IA and IB | 0.515 |
| hfq | shiA | b4172 | b1981 | Rna-binding protein hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Involved in the regulation of stress responses mediated by the sigma factors RpoS, sigma-E and sigma-32 . Binds with high specificity to tRNAs . Binds sRNA antitoxin RalA . In vitro, stimulates synthesis of long tails by poly(A) polymerase I . Required for RNA phage Qbeta replication . Seems to play a role in persister cell formation; upon overexpression decreas [...] | Mfs transporter, mhs family, shikimate and dehydroshikimate transport protein; Shikimate transporter; Pseudogene, glycosyltransferase homology | 0.560 |
| hfq | sodB | b4172 | b1656 | Rna-binding protein hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Involved in the regulation of stress responses mediated by the sigma factors RpoS, sigma-E and sigma-32 . Binds with high specificity to tRNAs . Binds sRNA antitoxin RalA . In vitro, stimulates synthesis of long tails by poly(A) polymerase I . Required for RNA phage Qbeta replication . Seems to play a role in persister cell formation; upon overexpression decreas [...] | Superoxide dismutase, fe-mn family; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems | 0.940 |
| shiA | amn | b1981 | b1982 | Mfs transporter, mhs family, shikimate and dehydroshikimate transport protein; Shikimate transporter; Pseudogene, glycosyltransferase homology | Amp nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations | 0.687 |
| shiA | aroE | b1981 | b3281 | Mfs transporter, mhs family, shikimate and dehydroshikimate transport protein; Shikimate transporter; Pseudogene, glycosyltransferase homology | Dehydroshikimate reductase, nad(p)-binding; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). It displays no activity in the presence of NAD | 0.450 |
| shiA | aroG | b1981 | b0754 | Mfs transporter, mhs family, shikimate and dehydroshikimate transport protein; Shikimate transporter; Pseudogene, glycosyltransferase homology | 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, phenylalanine repressible; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP) | 0.479 |
| shiA | cirA | b1981 | b2155 | Mfs transporter, mhs family, shikimate and dehydroshikimate transport protein; Shikimate transporter; Pseudogene, glycosyltransferase homology | Not yet known. Postulated to participate in iron transport. Outer membrane receptor for colicins IA and IB | 0.515 |
| shiA | cysE | b1981 | b3607 | Mfs transporter, mhs family, shikimate and dehydroshikimate transport protein; Shikimate transporter; Pseudogene, glycosyltransferase homology | Serine o-acetyltransferase; Belongs to the transferase hexapeptide repeat family | 0.481 |
| shiA | hfq | b1981 | b4172 | Mfs transporter, mhs family, shikimate and dehydroshikimate transport protein; Shikimate transporter; Pseudogene, glycosyltransferase homology | Rna-binding protein hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Involved in the regulation of stress responses mediated by the sigma factors RpoS, sigma-E and sigma-32 . Binds with high specificity to tRNAs . Binds sRNA antitoxin RalA . In vitro, stimulates synthesis of long tails by poly(A) polymerase I . Required for RNA phage Qbeta replication . Seems to play a role in persister cell formation; upon overexpression decreas [...] | 0.560 |
| shiA | sodB | b1981 | b1656 | Mfs transporter, mhs family, shikimate and dehydroshikimate transport protein; Shikimate transporter; Pseudogene, glycosyltransferase homology | Superoxide dismutase, fe-mn family; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems | 0.786 |
| shiA | ydeA | b1981 | b1528 | Mfs transporter, mhs family, shikimate and dehydroshikimate transport protein; Shikimate transporter; Pseudogene, glycosyltransferase homology | Mfs transporter, dha1 family, l-arabinose/isopropyl-beta-d-thiogalactopyranoside export protein; Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites. Transports L-arabinose and to a lesser extent IPTG. Seems to contribute to the control of the arabinose regulon | 0.545 |
| shiA | yeaV | b1981 | b1801 | Mfs transporter, mhs family, shikimate and dehydroshikimate transport protein; Shikimate transporter; Pseudogene, glycosyltransferase homology | Betaine/carnitine transporter, bcct family; Probable transporter whose substrate is unknown. Is not involved in aerobic D-malate transport | 0.629 |
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