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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
shiAMfs transporter, mhs family, shikimate and dehydroshikimate transport protein; Shikimate transporter; Pseudogene, glycosyltransferase homology (438 aa)    
Predicted Functional Partners:
sodB
Superoxide dismutase, fe-mn family; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems
     
 0.786
amn
Amp nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations
     
 0.687
yeaV
Betaine/carnitine transporter, bcct family; Probable transporter whose substrate is unknown. Is not involved in aerobic D-malate transport
      
 0.629
hfq
Rna-binding protein hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Involved in the regulation of stress responses mediated by the sigma factors RpoS, sigma-E and sigma-32 . Binds with high specificity to tRNAs . Binds sRNA antitoxin RalA . In vitro, stimulates synthesis of long tails by poly(A) polymerase I . Required for RNA phage Qbeta replication . Seems to play a role in persister cell formation; upon overexpression decreas [...]
      
 0.560
ydeA
Mfs transporter, dha1 family, l-arabinose/isopropyl-beta-d-thiogalactopyranoside export protein; Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites. Transports L-arabinose and to a lesser extent IPTG. Seems to contribute to the control of the arabinose regulon
    
 
 0.545
cirA
Not yet known. Postulated to participate in iron transport. Outer membrane receptor for colicins IA and IB
      
 0.515
cysE
Serine o-acetyltransferase; Belongs to the transferase hexapeptide repeat family
      
 0.481
aroG
3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, phenylalanine repressible; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP)
      
 0.479
yehX
Glycine betaine abc transporter atp binding subunit yehx; Part of an ABC transporter complex involved in low-affinity glycine betaine uptake. Probably responsible for energy coupling to the transport system
   
  
 0.479
aroE
Dehydroshikimate reductase, nad(p)-binding; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). It displays no activity in the presence of NAD
     
 0.450
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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