node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
adeD | amn | b3665 | b1982 | Cryptic adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family | Amp nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations | 0.913 |
adeD | deoD | b3665 | b4384 | Cryptic adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family | Purine nucleoside phosphorylase 1; Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules | 0.912 |
adeD | rihB | b3665 | b2162 | Cryptic adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family | Pyrimidine-specific ribonucleoside hydrolase rihb; Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides. Has a low but significant activity for the purine nucleoside xanthosine | 0.904 |
adeD | yaiE | b3665 | b0391 | Cryptic adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family | Purine/pyrimidine-nucleoside phosphorylase; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. Is not able to produce D-ribose 1-phosphate from D-ribose and phosphate | 0.900 |
adk | amn | b0474 | b1982 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism | Amp nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations | 0.905 |
adk | cpdA | b0474 | b3032 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism | 3',5'-cyclic-AMP phosphodiesterase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. Specific for cAMP | 0.902 |
adk | mazG | b0474 | b2781 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism | Nucleoside triphosphate pyrophosphohydrolase; Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the type II MazE-MazF toxin-antitoxin (TA) system which mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp produced by RelA under amino acid starvation, thus protecting the cell from the toxicity of MazF. Reduction of (p)ppGpp can be achieved by direct degradation of (p)ppGpp or by degradation of NTPs, which are substrates for (p)ppGpp synthesis by RelA | 0.929 |
adk | purB | b0474 | b1131 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism | Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily | 0.945 |
adk | umpG | b0474 | b2744 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism | Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. Also plays a significant physiological role in stress-response and is [...] | 0.917 |
adk | ushA | b0474 | b0480 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism | Bifunctional udp-sugar hydrolase/5'-nucleotidase; Degradation of external UDP-glucose to uridine monophosphate and glucose-1-phosphate, which can then be used by the cell | 0.900 |
amn | adeD | b1982 | b3665 | Amp nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations | Cryptic adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family | 0.913 |
amn | adk | b1982 | b0474 | Amp nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism | 0.905 |
amn | cpdA | b1982 | b3032 | Amp nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations | 3',5'-cyclic-AMP phosphodiesterase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. Specific for cAMP | 0.900 |
amn | deoD | b1982 | b4384 | Amp nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations | Purine nucleoside phosphorylase 1; Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules | 0.958 |
amn | mazG | b1982 | b2781 | Amp nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations | Nucleoside triphosphate pyrophosphohydrolase; Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the type II MazE-MazF toxin-antitoxin (TA) system which mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp produced by RelA under amino acid starvation, thus protecting the cell from the toxicity of MazF. Reduction of (p)ppGpp can be achieved by direct degradation of (p)ppGpp or by degradation of NTPs, which are substrates for (p)ppGpp synthesis by RelA | 0.903 |
amn | purB | b1982 | b1131 | Amp nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations | Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily | 0.904 |
amn | rihB | b1982 | b2162 | Amp nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations | Pyrimidine-specific ribonucleoside hydrolase rihb; Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides. Has a low but significant activity for the purine nucleoside xanthosine | 0.900 |
amn | umpG | b1982 | b2744 | Amp nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations | Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. Also plays a significant physiological role in stress-response and is [...] | 0.900 |
amn | ushA | b1982 | b0480 | Amp nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations | Bifunctional udp-sugar hydrolase/5'-nucleotidase; Degradation of external UDP-glucose to uridine monophosphate and glucose-1-phosphate, which can then be used by the cell | 0.900 |
amn | yaiE | b1982 | b0391 | Amp nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations | Purine/pyrimidine-nucleoside phosphorylase; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. Is not able to produce D-ribose 1-phosphate from D-ribose and phosphate | 0.901 |