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STRING protein interaction network
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
Your Input:
Gene Fusion
yeeSCP4-44 prophage; RadC-like JAB domain-containing protein YeeS; Belongs to the UPF0758 family (148 aa)    
Predicted Functional Partners:
CP4-44 prophage; inner membrane protein YeeR; Inner membrane protein YeeR; Phage or Prophage Related
Uncharacterized protein YeeT; Phage or Prophage Related; Belongs to the YeeT/YkfH/YpjJ family
Cytoskeleton bundling-enhancing protein cbea and related proteins; Antitoxin component of a type IV toxin-antitoxin (TA) system . Antitoxin that counteracts the effect of its cognate toxin CbtA (YeeV) . It does not bind to the toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles; it is probably retained in the MreB and FtsZ filament bundles . The mechanism has been proposed to require intergenic DNA, in cis, between the cbeA (yeeU) and cbta (yeeV) genes . The intergenic region was not found to be necessary in anoth [...]
Putative m28a family peptidase; Uncharacterized protein YfbL; Putative aminopeptidase
Toxic component of a type IV toxin-antitoxin (TA) system Acts as a dual toxin inhibitor that blocks cell division and cell elongation in genetically separable interactions with FtsZ and MreB . Interacts with cytoskeletal proteins FtsZ and MreB; inhibits FtsZ GTP-dependent polymerization and GTPase activity as well as MreB ATP-dependent polymerization Binds to both the N- and C-terminus of FtsZ, likely blocking its polymerization and localization, leading to blockage of cell division . Overexpression results in inhibition of growth in liquid cultures and decrease in colony formation; th [...]
CP4-6 prophage; conserved protein YafZ; Belongs to the UPF0380 family
Rac prophage; putative atp-binding protein ydav; Uncharacterized protein YdaV; Putative DNA replication factor
CP4-44 prophage; self recognizing antigen 43 (Ag43) autotransporter; Controls colony form variation and autoaggregation. May function as an adhesin
Dna recombination-mediator a family protein; Partially complements natural chromosomal DNA transformation defect of an H.influenzae dprA disruption mutant . May help load RecA onto ssDNA (By similarity)
Molybdate transport system atp-binding protein; Probably not involved in the transport of molybdenum into the cell
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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