| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cbeA | cbtA | b2004 | b2005 | Cytoskeleton bundling-enhancing protein cbea and related proteins; Antitoxin component of a type IV toxin-antitoxin (TA) system . Antitoxin that counteracts the effect of its cognate toxin CbtA (YeeV) . It does not bind to the toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles; it is probably retained in the MreB and FtsZ filament bundles . The mechanism has been proposed to require intergenic DNA, in cis, between the cbeA (yeeU) and cbta (yeeV) genes . The intergenic region was not found to be necessary in anoth [...] | Toxic component of a type IV toxin-antitoxin (TA) system Acts as a dual toxin inhibitor that blocks cell division and cell elongation in genetically separable interactions with FtsZ and MreB . Interacts with cytoskeletal proteins FtsZ and MreB; inhibits FtsZ GTP-dependent polymerization and GTPase activity as well as MreB ATP-dependent polymerization Binds to both the N- and C-terminus of FtsZ, likely blocking its polymerization and localization, leading to blockage of cell division . Overexpression results in inhibition of growth in liquid cultures and decrease in colony formation; th [...] | 0.998 |
| cbeA | cptA | b2004 | b2896 | Cytoskeleton bundling-enhancing protein cbea and related proteins; Antitoxin component of a type IV toxin-antitoxin (TA) system . Antitoxin that counteracts the effect of its cognate toxin CbtA (YeeV) . It does not bind to the toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles; it is probably retained in the MreB and FtsZ filament bundles . The mechanism has been proposed to require intergenic DNA, in cis, between the cbeA (yeeU) and cbta (yeeV) genes . The intergenic region was not found to be necessary in anoth [...] | A probable inner membrane protein. Has been shown not to be a toxin, no effects on growth are seen in LB or minimal medium up to 6 or 21 hours (respectively) after induction of expression . Interacts with cytoskeletal proteins FtsZ and MreB; inhibits FtsZ GTP-dependent polymerization as well as MreB ATP- dependent polymerization . Restores production of prodigiosin antibiotic (Pig) in Serratia strains with deletions of sdhE-ygfX; overexpression of this protein and CptB also restores Pig production to a slightly lesser extent in Serratia | 0.876 |
| cbeA | ftsZ | b2004 | b0095 | Cytoskeleton bundling-enhancing protein cbea and related proteins; Antitoxin component of a type IV toxin-antitoxin (TA) system . Antitoxin that counteracts the effect of its cognate toxin CbtA (YeeV) . It does not bind to the toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles; it is probably retained in the MreB and FtsZ filament bundles . The mechanism has been proposed to require intergenic DNA, in cis, between the cbeA (yeeU) and cbta (yeeV) genes . The intergenic region was not found to be necessary in anoth [...] | Gtp-binding tubulin-like cell division protein; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. Polymerization and bundle formation is enhanced by CbeA | 0.902 |
| cbeA | ghoT | b2004 | b4559 | Cytoskeleton bundling-enhancing protein cbea and related proteins; Antitoxin component of a type IV toxin-antitoxin (TA) system . Antitoxin that counteracts the effect of its cognate toxin CbtA (YeeV) . It does not bind to the toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles; it is probably retained in the MreB and FtsZ filament bundles . The mechanism has been proposed to require intergenic DNA, in cis, between the cbeA (yeeU) and cbta (yeeV) genes . The intergenic region was not found to be necessary in anoth [...] | Toxic component of a type V toxin-antitoxin (TA) system. Causes membrane damage when induced by MqsR, slowing cell growth and increasing the formation of dormant persister cells; involved with GhoS, its antitoxin, in reducing cell growth during antibacterial stress . Overexpression causes cell lysis, forming ghost cells; both effects are neutralized by expression of GhoS. Overexpression in the presence of ampicillin increases persister cell formation (persister cells exhibit antibiotic tolerance without genetic change) . Overexpression causes about 90-fold reduction in cellular ATP lev [...] | 0.875 |
| cbeA | mreB | b2004 | b3251 | Cytoskeleton bundling-enhancing protein cbea and related proteins; Antitoxin component of a type IV toxin-antitoxin (TA) system . Antitoxin that counteracts the effect of its cognate toxin CbtA (YeeV) . It does not bind to the toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles; it is probably retained in the MreB and FtsZ filament bundles . The mechanism has been proposed to require intergenic DNA, in cis, between the cbeA (yeeU) and cbta (yeeV) genes . The intergenic region was not found to be necessary in anoth [...] | Cell wall structural complex mrebcd, actin-like component mreb; Forms membrane-associated dynamic filaments that are essential for cell shape determination Acts by regulating cell wall synthesis and cell elongation, and thus cell shape . A feedback loop between cell geometry and MreB localization maintains elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature . Filaments rotate around the cell circumference in concert with the cell wall synthesis enzymes. The process is driven by the cell wall synthesis machinery and does not depend on MreB polym [...] | 0.916 |
| cbeA | yeeR | b2004 | b2001 | Cytoskeleton bundling-enhancing protein cbea and related proteins; Antitoxin component of a type IV toxin-antitoxin (TA) system . Antitoxin that counteracts the effect of its cognate toxin CbtA (YeeV) . It does not bind to the toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles; it is probably retained in the MreB and FtsZ filament bundles . The mechanism has been proposed to require intergenic DNA, in cis, between the cbeA (yeeU) and cbta (yeeV) genes . The intergenic region was not found to be necessary in anoth [...] | CP4-44 prophage; inner membrane protein YeeR; Inner membrane protein YeeR; Phage or Prophage Related | 0.886 |
| cbeA | yeeT | b2004 | b2003 | Cytoskeleton bundling-enhancing protein cbea and related proteins; Antitoxin component of a type IV toxin-antitoxin (TA) system . Antitoxin that counteracts the effect of its cognate toxin CbtA (YeeV) . It does not bind to the toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles; it is probably retained in the MreB and FtsZ filament bundles . The mechanism has been proposed to require intergenic DNA, in cis, between the cbeA (yeeU) and cbta (yeeV) genes . The intergenic region was not found to be necessary in anoth [...] | Uncharacterized protein YeeT; Phage or Prophage Related; Belongs to the YeeT/YkfH/YpjJ family | 0.946 |
| cbeA | ykfH | b2004 | b4504 | Cytoskeleton bundling-enhancing protein cbea and related proteins; Antitoxin component of a type IV toxin-antitoxin (TA) system . Antitoxin that counteracts the effect of its cognate toxin CbtA (YeeV) . It does not bind to the toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles; it is probably retained in the MreB and FtsZ filament bundles . The mechanism has been proposed to require intergenic DNA, in cis, between the cbeA (yeeU) and cbta (yeeV) genes . The intergenic region was not found to be necessary in anoth [...] | DUF987 domain-containing protein YkfH; Belongs to the YeeT/YkfH/YpjJ family | 0.809 |
| cbtA | cbeA | b2005 | b2004 | Toxic component of a type IV toxin-antitoxin (TA) system Acts as a dual toxin inhibitor that blocks cell division and cell elongation in genetically separable interactions with FtsZ and MreB . Interacts with cytoskeletal proteins FtsZ and MreB; inhibits FtsZ GTP-dependent polymerization and GTPase activity as well as MreB ATP-dependent polymerization Binds to both the N- and C-terminus of FtsZ, likely blocking its polymerization and localization, leading to blockage of cell division . Overexpression results in inhibition of growth in liquid cultures and decrease in colony formation; th [...] | Cytoskeleton bundling-enhancing protein cbea and related proteins; Antitoxin component of a type IV toxin-antitoxin (TA) system . Antitoxin that counteracts the effect of its cognate toxin CbtA (YeeV) . It does not bind to the toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles; it is probably retained in the MreB and FtsZ filament bundles . The mechanism has been proposed to require intergenic DNA, in cis, between the cbeA (yeeU) and cbta (yeeV) genes . The intergenic region was not found to be necessary in anoth [...] | 0.998 |
| cbtA | cptA | b2005 | b2896 | Toxic component of a type IV toxin-antitoxin (TA) system Acts as a dual toxin inhibitor that blocks cell division and cell elongation in genetically separable interactions with FtsZ and MreB . Interacts with cytoskeletal proteins FtsZ and MreB; inhibits FtsZ GTP-dependent polymerization and GTPase activity as well as MreB ATP-dependent polymerization Binds to both the N- and C-terminus of FtsZ, likely blocking its polymerization and localization, leading to blockage of cell division . Overexpression results in inhibition of growth in liquid cultures and decrease in colony formation; th [...] | A probable inner membrane protein. Has been shown not to be a toxin, no effects on growth are seen in LB or minimal medium up to 6 or 21 hours (respectively) after induction of expression . Interacts with cytoskeletal proteins FtsZ and MreB; inhibits FtsZ GTP-dependent polymerization as well as MreB ATP- dependent polymerization . Restores production of prodigiosin antibiotic (Pig) in Serratia strains with deletions of sdhE-ygfX; overexpression of this protein and CptB also restores Pig production to a slightly lesser extent in Serratia | 0.812 |
| cbtA | ftsZ | b2005 | b0095 | Toxic component of a type IV toxin-antitoxin (TA) system Acts as a dual toxin inhibitor that blocks cell division and cell elongation in genetically separable interactions with FtsZ and MreB . Interacts with cytoskeletal proteins FtsZ and MreB; inhibits FtsZ GTP-dependent polymerization and GTPase activity as well as MreB ATP-dependent polymerization Binds to both the N- and C-terminus of FtsZ, likely blocking its polymerization and localization, leading to blockage of cell division . Overexpression results in inhibition of growth in liquid cultures and decrease in colony formation; th [...] | Gtp-binding tubulin-like cell division protein; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. Polymerization and bundle formation is enhanced by CbeA | 0.881 |
| cbtA | ghoT | b2005 | b4559 | Toxic component of a type IV toxin-antitoxin (TA) system Acts as a dual toxin inhibitor that blocks cell division and cell elongation in genetically separable interactions with FtsZ and MreB . Interacts with cytoskeletal proteins FtsZ and MreB; inhibits FtsZ GTP-dependent polymerization and GTPase activity as well as MreB ATP-dependent polymerization Binds to both the N- and C-terminus of FtsZ, likely blocking its polymerization and localization, leading to blockage of cell division . Overexpression results in inhibition of growth in liquid cultures and decrease in colony formation; th [...] | Toxic component of a type V toxin-antitoxin (TA) system. Causes membrane damage when induced by MqsR, slowing cell growth and increasing the formation of dormant persister cells; involved with GhoS, its antitoxin, in reducing cell growth during antibacterial stress . Overexpression causes cell lysis, forming ghost cells; both effects are neutralized by expression of GhoS. Overexpression in the presence of ampicillin increases persister cell formation (persister cells exhibit antibiotic tolerance without genetic change) . Overexpression causes about 90-fold reduction in cellular ATP lev [...] | 0.818 |
| cbtA | mreB | b2005 | b3251 | Toxic component of a type IV toxin-antitoxin (TA) system Acts as a dual toxin inhibitor that blocks cell division and cell elongation in genetically separable interactions with FtsZ and MreB . Interacts with cytoskeletal proteins FtsZ and MreB; inhibits FtsZ GTP-dependent polymerization and GTPase activity as well as MreB ATP-dependent polymerization Binds to both the N- and C-terminus of FtsZ, likely blocking its polymerization and localization, leading to blockage of cell division . Overexpression results in inhibition of growth in liquid cultures and decrease in colony formation; th [...] | Cell wall structural complex mrebcd, actin-like component mreb; Forms membrane-associated dynamic filaments that are essential for cell shape determination Acts by regulating cell wall synthesis and cell elongation, and thus cell shape . A feedback loop between cell geometry and MreB localization maintains elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature . Filaments rotate around the cell circumference in concert with the cell wall synthesis enzymes. The process is driven by the cell wall synthesis machinery and does not depend on MreB polym [...] | 0.808 |
| cbtA | yafW | b2005 | b0246 | Toxic component of a type IV toxin-antitoxin (TA) system Acts as a dual toxin inhibitor that blocks cell division and cell elongation in genetically separable interactions with FtsZ and MreB . Interacts with cytoskeletal proteins FtsZ and MreB; inhibits FtsZ GTP-dependent polymerization and GTPase activity as well as MreB ATP-dependent polymerization Binds to both the N- and C-terminus of FtsZ, likely blocking its polymerization and localization, leading to blockage of cell division . Overexpression results in inhibition of growth in liquid cultures and decrease in colony formation; th [...] | Cytoskeleton bundling-enhancing protein cbea and related proteins; Antitoxin component of a type IV toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of cognate toxin YkfI . It does not seem to bind to the cognate toxin but instead induces toxin loss by an unknown mechanism . Co-overexpression of toxin YkfI and antitoxin YafW leads to formation of elongated cells | 0.961 |
| cbtA | yeeR | b2005 | b2001 | Toxic component of a type IV toxin-antitoxin (TA) system Acts as a dual toxin inhibitor that blocks cell division and cell elongation in genetically separable interactions with FtsZ and MreB . Interacts with cytoskeletal proteins FtsZ and MreB; inhibits FtsZ GTP-dependent polymerization and GTPase activity as well as MreB ATP-dependent polymerization Binds to both the N- and C-terminus of FtsZ, likely blocking its polymerization and localization, leading to blockage of cell division . Overexpression results in inhibition of growth in liquid cultures and decrease in colony formation; th [...] | CP4-44 prophage; inner membrane protein YeeR; Inner membrane protein YeeR; Phage or Prophage Related | 0.829 |
| cbtA | yeeT | b2005 | b2003 | Toxic component of a type IV toxin-antitoxin (TA) system Acts as a dual toxin inhibitor that blocks cell division and cell elongation in genetically separable interactions with FtsZ and MreB . Interacts with cytoskeletal proteins FtsZ and MreB; inhibits FtsZ GTP-dependent polymerization and GTPase activity as well as MreB ATP-dependent polymerization Binds to both the N- and C-terminus of FtsZ, likely blocking its polymerization and localization, leading to blockage of cell division . Overexpression results in inhibition of growth in liquid cultures and decrease in colony formation; th [...] | Uncharacterized protein YeeT; Phage or Prophage Related; Belongs to the YeeT/YkfH/YpjJ family | 0.915 |
| cbtA | yfjZ | b2005 | b2645 | Toxic component of a type IV toxin-antitoxin (TA) system Acts as a dual toxin inhibitor that blocks cell division and cell elongation in genetically separable interactions with FtsZ and MreB . Interacts with cytoskeletal proteins FtsZ and MreB; inhibits FtsZ GTP-dependent polymerization and GTPase activity as well as MreB ATP-dependent polymerization Binds to both the N- and C-terminus of FtsZ, likely blocking its polymerization and localization, leading to blockage of cell division . Overexpression results in inhibition of growth in liquid cultures and decrease in colony formation; th [...] | CP4-57 prophage; putative antitoxin of the YpjF-YfjZ toxin-antitoxin system; Antitoxin component of a type IV toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of cognate toxin YpjF . Also counteracts the effect of non-cognate toxins CbtA and YfkI | 0.951 |
| cbtA | ykfH | b2005 | b4504 | Toxic component of a type IV toxin-antitoxin (TA) system Acts as a dual toxin inhibitor that blocks cell division and cell elongation in genetically separable interactions with FtsZ and MreB . Interacts with cytoskeletal proteins FtsZ and MreB; inhibits FtsZ GTP-dependent polymerization and GTPase activity as well as MreB ATP-dependent polymerization Binds to both the N- and C-terminus of FtsZ, likely blocking its polymerization and localization, leading to blockage of cell division . Overexpression results in inhibition of growth in liquid cultures and decrease in colony formation; th [...] | DUF987 domain-containing protein YkfH; Belongs to the YeeT/YkfH/YpjJ family | 0.807 |
| cptA | cbeA | b2896 | b2004 | A probable inner membrane protein. Has been shown not to be a toxin, no effects on growth are seen in LB or minimal medium up to 6 or 21 hours (respectively) after induction of expression . Interacts with cytoskeletal proteins FtsZ and MreB; inhibits FtsZ GTP-dependent polymerization as well as MreB ATP- dependent polymerization . Restores production of prodigiosin antibiotic (Pig) in Serratia strains with deletions of sdhE-ygfX; overexpression of this protein and CptB also restores Pig production to a slightly lesser extent in Serratia | Cytoskeleton bundling-enhancing protein cbea and related proteins; Antitoxin component of a type IV toxin-antitoxin (TA) system . Antitoxin that counteracts the effect of its cognate toxin CbtA (YeeV) . It does not bind to the toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles; it is probably retained in the MreB and FtsZ filament bundles . The mechanism has been proposed to require intergenic DNA, in cis, between the cbeA (yeeU) and cbta (yeeV) genes . The intergenic region was not found to be necessary in anoth [...] | 0.876 |
| cptA | cbtA | b2896 | b2005 | A probable inner membrane protein. Has been shown not to be a toxin, no effects on growth are seen in LB or minimal medium up to 6 or 21 hours (respectively) after induction of expression . Interacts with cytoskeletal proteins FtsZ and MreB; inhibits FtsZ GTP-dependent polymerization as well as MreB ATP- dependent polymerization . Restores production of prodigiosin antibiotic (Pig) in Serratia strains with deletions of sdhE-ygfX; overexpression of this protein and CptB also restores Pig production to a slightly lesser extent in Serratia | Toxic component of a type IV toxin-antitoxin (TA) system Acts as a dual toxin inhibitor that blocks cell division and cell elongation in genetically separable interactions with FtsZ and MreB . Interacts with cytoskeletal proteins FtsZ and MreB; inhibits FtsZ GTP-dependent polymerization and GTPase activity as well as MreB ATP-dependent polymerization Binds to both the N- and C-terminus of FtsZ, likely blocking its polymerization and localization, leading to blockage of cell division . Overexpression results in inhibition of growth in liquid cultures and decrease in colony formation; th [...] | 0.812 |
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