| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| csgA | mliC | b1042 | b1639 | Curlin subunit, amyloid curli fibers, cryptic; Curlin is the structural subunit of the curli fimbriae. Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin | Inhibitor of c-type lysozyme, putative lipoprotein; Specifically inhibits C-type lysozymes | 0.406 |
| csgA | sbmC | b1042 | b2009 | Curlin subunit, amyloid curli fibers, cryptic; Curlin is the structural subunit of the curli fimbriae. Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin | Dna gyrase inhibitor; Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell. Protects cells against the natural plasmid-encoded toxins microcin B17 (MccB17) and CcdB, and synthetic quinolones. Can also protect cells against alkylating agents that act independently of DNA gyrase, suggesting a more general role in protectin [...] | 0.654 |
| csgA | yjfY | b1042 | b4199 | Curlin subunit, amyloid curli fibers, cryptic; Curlin is the structural subunit of the curli fimbriae. Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin | annotation not available | 0.433 |
| gyrA | gyrB | b2231 | b3699 | A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than many other bacterial gyrases; at comparable concentrations [...] | DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase 4 (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than other characterized bacterial gyrases; at comparable concentrations [...] | 0.999 |
| gyrA | sbmC | b2231 | b2009 | A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than many other bacterial gyrases; at comparable concentrations [...] | Dna gyrase inhibitor; Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell. Protects cells against the natural plasmid-encoded toxins microcin B17 (MccB17) and CcdB, and synthetic quinolones. Can also protect cells against alkylating agents that act independently of DNA gyrase, suggesting a more general role in protectin [...] | 0.600 |
| gyrB | gyrA | b3699 | b2231 | DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase 4 (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than other characterized bacterial gyrases; at comparable concentrations [...] | A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than many other bacterial gyrases; at comparable concentrations [...] | 0.999 |
| gyrB | sbmC | b3699 | b2009 | DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase 4 (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than other characterized bacterial gyrases; at comparable concentrations [...] | Dna gyrase inhibitor; Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell. Protects cells against the natural plasmid-encoded toxins microcin B17 (MccB17) and CcdB, and synthetic quinolones. Can also protect cells against alkylating agents that act independently of DNA gyrase, suggesting a more general role in protectin [...] | 0.650 |
| mliC | csgA | b1639 | b1042 | Inhibitor of c-type lysozyme, putative lipoprotein; Specifically inhibits C-type lysozymes | Curlin subunit, amyloid curli fibers, cryptic; Curlin is the structural subunit of the curli fimbriae. Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin | 0.406 |
| mliC | sbmC | b1639 | b2009 | Inhibitor of c-type lysozyme, putative lipoprotein; Specifically inhibits C-type lysozymes | Dna gyrase inhibitor; Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell. Protects cells against the natural plasmid-encoded toxins microcin B17 (MccB17) and CcdB, and synthetic quinolones. Can also protect cells against alkylating agents that act independently of DNA gyrase, suggesting a more general role in protectin [...] | 0.622 |
| recN | sbmC | b2616 | b2009 | Dna repair protein recn (recombination protein n); May be involved in recombinational repair of damaged DNA | Dna gyrase inhibitor; Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell. Protects cells against the natural plasmid-encoded toxins microcin B17 (MccB17) and CcdB, and synthetic quinolones. Can also protect cells against alkylating agents that act independently of DNA gyrase, suggesting a more general role in protectin [...] | 0.641 |
| recN | umuD | b2616 | b1183 | Dna repair protein recn (recombination protein n); May be involved in recombinational repair of damaged DNA | Involved in UV protection and mutation. Poorly processive, error-prone DNA polymerase involved in translesion repair . Essential for induced (or SOS) mutagenesis. Able to replicate DNA across DNA lesions (thymine photodimers and abasic sites, called translesion synthesis) in the presence of activated RecA; efficiency is maximal in the presence of the beta sliding-clamp and clamp-loading complex of DNA polymerase III plus single-stranded binding protein (SSB) . RecA and to a lesser extent the beta clamp-complex may target Pol V to replication complexes stalled at DNA template lesions | 0.906 |
| recN | ybfE | b2616 | b0685 | Dna repair protein recn (recombination protein n); May be involved in recombinational repair of damaged DNA | Lexa-regulated protein, copb family; Uncharacterized protein YbfE; Protein involved in SOS response | 0.570 |
| recN | yebG | b2616 | b1848 | Dna repair protein recn (recombination protein n); May be involved in recombinational repair of damaged DNA | Dna damage-inducible protein regulated by lexa; Uncharacterized protein YebG; Protein involved in DNA repair and SOS response | 0.913 |
| sbmC | csgA | b2009 | b1042 | Dna gyrase inhibitor; Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell. Protects cells against the natural plasmid-encoded toxins microcin B17 (MccB17) and CcdB, and synthetic quinolones. Can also protect cells against alkylating agents that act independently of DNA gyrase, suggesting a more general role in protectin [...] | Curlin subunit, amyloid curli fibers, cryptic; Curlin is the structural subunit of the curli fimbriae. Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin | 0.654 |
| sbmC | gyrA | b2009 | b2231 | Dna gyrase inhibitor; Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell. Protects cells against the natural plasmid-encoded toxins microcin B17 (MccB17) and CcdB, and synthetic quinolones. Can also protect cells against alkylating agents that act independently of DNA gyrase, suggesting a more general role in protectin [...] | A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than many other bacterial gyrases; at comparable concentrations [...] | 0.600 |
| sbmC | gyrB | b2009 | b3699 | Dna gyrase inhibitor; Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell. Protects cells against the natural plasmid-encoded toxins microcin B17 (MccB17) and CcdB, and synthetic quinolones. Can also protect cells against alkylating agents that act independently of DNA gyrase, suggesting a more general role in protectin [...] | DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase 4 (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than other characterized bacterial gyrases; at comparable concentrations [...] | 0.650 |
| sbmC | mliC | b2009 | b1639 | Dna gyrase inhibitor; Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell. Protects cells against the natural plasmid-encoded toxins microcin B17 (MccB17) and CcdB, and synthetic quinolones. Can also protect cells against alkylating agents that act independently of DNA gyrase, suggesting a more general role in protectin [...] | Inhibitor of c-type lysozyme, putative lipoprotein; Specifically inhibits C-type lysozymes | 0.622 |
| sbmC | recN | b2009 | b2616 | Dna gyrase inhibitor; Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell. Protects cells against the natural plasmid-encoded toxins microcin B17 (MccB17) and CcdB, and synthetic quinolones. Can also protect cells against alkylating agents that act independently of DNA gyrase, suggesting a more general role in protectin [...] | Dna repair protein recn (recombination protein n); May be involved in recombinational repair of damaged DNA | 0.641 |
| sbmC | umuD | b2009 | b1183 | Dna gyrase inhibitor; Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell. Protects cells against the natural plasmid-encoded toxins microcin B17 (MccB17) and CcdB, and synthetic quinolones. Can also protect cells against alkylating agents that act independently of DNA gyrase, suggesting a more general role in protectin [...] | Involved in UV protection and mutation. Poorly processive, error-prone DNA polymerase involved in translesion repair . Essential for induced (or SOS) mutagenesis. Able to replicate DNA across DNA lesions (thymine photodimers and abasic sites, called translesion synthesis) in the presence of activated RecA; efficiency is maximal in the presence of the beta sliding-clamp and clamp-loading complex of DNA polymerase III plus single-stranded binding protein (SSB) . RecA and to a lesser extent the beta clamp-complex may target Pol V to replication complexes stalled at DNA template lesions | 0.586 |
| sbmC | ybfE | b2009 | b0685 | Dna gyrase inhibitor; Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell. Protects cells against the natural plasmid-encoded toxins microcin B17 (MccB17) and CcdB, and synthetic quinolones. Can also protect cells against alkylating agents that act independently of DNA gyrase, suggesting a more general role in protectin [...] | Lexa-regulated protein, copb family; Uncharacterized protein YbfE; Protein involved in SOS response | 0.820 |
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