STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yeeYUncharacterized HTH-type transcriptional regulator YeeY; Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription (309 aa)    
Predicted Functional Partners:
yeeZ
Protein YeeZ; Putative enzyme of sugar metabolism; Protein involved in carbohydrate catabolic process
  
    0.702
yefM
Antitoxin YefM; Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of the YoeB toxin. YefM binds to the promoter region of the yefM-yeoB operon to repress transcription, YeoB acts as a corepressor
       0.508
yoeB
Toxin YoeB; Toxic component of a type II toxin-antitoxin (TA) system. Its mode of function is controversial; it has been proposed to be an mRNA interferase but also an inhibitor of translation initiation. When overproduced in wild-type cells, inhibits bacterial growth and translation by cleavage of mRNA molecules while it has a weak effect on colony forming ability. Overproduction of Lon protease specifically activates YoeB- dependent mRNA cleavage, leading to lethality. YefM binds to the promoter region of the yefM-yeoB operon to repress transcription, YeoB acts as a corepressor
       0.508
yhjY
Uncharacterized protein YhjY; Putative lipase; Protein involved in fatty acid oxidation
  
    0.462
plaP
Low-affinity putrescine importer PlaP; Putrescine importer. Required for induction of type 1 pili-driven surface motility
       0.459
yoeI
annotation not available
       0.459
yhjC
Uncharacterized HTH-type transcriptional regulator YhjC; Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription
  
    0.403
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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