STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yeeZProtein YeeZ; Putative enzyme of sugar metabolism; Protein involved in carbohydrate catabolic process (274 aa)    
Predicted Functional Partners:
yeeN
Putative transcriptional regulator yeen; Belongs to the TACO1 family. YeeN subfamily
    
   0.870
yefM
Yefm antitoxin of the yoeb-yefm toxin-antitoxin pair and dna binding transcriptional repressor; Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of the YoeB toxin. YefM binds to the promoter region of the yefM-yeoB operon to repress transcription, YeoB acts as a corepressor
  
  
 0.731
plaP
Putrescine importer, low affinity; Putrescine importer. Required for induction of type 1 pili- driven surface motility
     
 0.720
yeeE
UPF0394 inner membrane protein YeeE; Putative transport system permease protein
     
 0.706
yeeY
Putative dna-binding transcriptional regulator yeey; Belongs to the LysR transcriptional regulatory family
  
    0.702
yoeB
Toxic component of a type II toxin-antitoxin (TA) system. Its mode of function is controversial; it has been proposed to be an mRNA interferase but also an inhibitor of translation initiation. When overproduced in wild-type cells, inhibits bacterial growth and translation by cleavage of mRNA molecules while it has a weak effect on colony forming ability. Overproduction of Lon protease specifically activates YoeB-dependent mRNA cleavage, leading to lethality. YefM binds to the promoter region of the yefM-yeoB operon to repress transcription, YeoB acts as a corepressor. Also shown in vit [...]
     
 0.702
yeeD
annotation not available
     
 0.695
cpsB
Mannose-1-phosphate guanylyltransferase; Involved in the biosynthesis of the capsular polysaccharide colanic acid
     
 0.641
ucpA
Furfural resistance protein, putative short-chain oxidoreductase; Putative oxidoreductase
   
 
 0.639
hldE
D-beta-d-heptose 7-phosphate kinase / d-beta-d-heptose 1-phosphate adenosyltransferase; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate
  
  
 0.633
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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