STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
wzxCM-antigen undecaprenyl disphosphate flippase; Belongs to the polysaccharide synthase family (492 aa)    
Predicted Functional Partners:
wcaJ
Putative colanic acid biosysnthesis udp-glucose lipid carrier transferase; Is the initiating enzyme for colanic acid (CA) synthesis. Catalyzes the transfer of the glucose-1-phosphate moiety from UDP-Glc onto the carrier lipid undecaprenyl phosphate (C55-P), forming a phosphoanhydride bond yielding to glucosyl-pyrophosphoryl-undecaprenol (Glc-PP-C55). Also possesses a weak galactose-1-P transferase activity
 
  
 0.994
wzyE
Putative eca polysaccharide chain elongation protein; Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units. Required for the assembly of the phosphoglyceride-linked form of ECA (ECA(PG)) and the water-soluble cyclic form of ECA (ECA(CYC))
  
 
 0.973
wzc
Colanic acid production tyrosine-protein kinase; Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium. Phosphorylates udg
 
  
 0.967
wza
Outer membrane polysaccharide export protein wza; Probably involved in the export of the extracellular polysaccharide colanic acid from the cell to medium
 
 
 0.956
wcaK
Putative colanic acid biosynthesis pyruvyl transferase; Putative galactokinase; Protein involved in colanic acid biosynthetic process
 
  
 0.952
cpsG
Phosphomannomutase; Involved in the biosynthesis of the capsular polysaccharide colanic acid
 
  
 0.944
wzzB
Chain length determinant protein (polysaccharide antigen chain regulator); Confers a modal distribution of chain length on the O-antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules
 
  
 0.941
wbbH
Putative o-antigen polymerase; May link the O-antigen tetrasaccharide units into long chains, giving rise to typical smooth LPS
     
 0.931
wcaA
Putative colanic acid biosynthesis glycosyl transferase WcaA; Putative regulator; Protein involved in colanic acid biosynthetic process
 
  
 0.930
wzb
Colanic acid production protein-tyrosine-phosphatase; Dephosphorylates Wzc . Required for the extracellular polysaccharide colanic acid synthesis, probably involved in the export of colanic acid from the cell to medium . Involved in protection of cells against contact- dependent growth inhibition (CDI), probably due to the loss of a physical impediment to cell-cell contact
 
   
 0.930
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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