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wcaJ protein (Escherichia coli K12 MG1655) - STRING interaction network
"wcaJ" - UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferase in Escherichia coli K12 MG1655
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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wcaJUDP-glucose-undecaprenyl-phosphate glucose-1-phosphate transferase; Is the initiating enzyme for colanic acid (CA) synthesis. Catalyzes the transfer of the glucose-1-phosphate moiety from UDP-Glc onto the carrier lipid undecaprenyl phosphate (C55-P), forming a phosphoanhydride bond yielding to glucosyl- pyrophosphoryl-undecaprenol (Glc-PP-C55). Also possesses a weak galactose-1-P transferase activity; Belongs to the bacterial sugar transferase family (464 aa)    
Predicted Functional Partners:
wzxC
Lipopolysaccharide biosynthesis protein WzxC; Probable export protein; Belongs to the polysaccharide synthase family (492 aa)
 
   
  0.993
cpsB
Mannose-1-phosphate guanylyltransferase; Involved in the biosynthesis of the capsular polysaccharide colanic acid (478 aa)
 
   
  0.979
wzc
Tyrosine-protein kinase wzc; Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium. Phosphorylates udg (720 aa)
   
  0.970
cpsG
Phosphomannomutase; Involved in the biosynthesis of the capsular polysaccharide colanic acid; Belongs to the phosphohexose mutase family (456 aa)
 
   
  0.960
wcaK
Putative galactokinase; Protein involved in colanic acid biosynthetic process (426 aa)
 
   
  0.959
wcaM
Putative colanic acid biosynthesis protein; Protein involved in colanic acid biosynthetic process (464 aa)
 
   
  0.942
wcaA
Putative colanic acid biosynthesis glycosyl transferase WcaA; Putative regulator; Protein involved in colanic acid biosynthetic process (279 aa)
   
  0.936
wcaI
Putative colanic biosynthesis glycosyl transferase; Protein involved in colanic acid biosynthetic process (407 aa)
   
  0.928
gmd
GDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily (373 aa)
   
   
  0.908
wzb
Low molecular weight protein-tyrosine-phosphatase Wzb; Dephosphorylates Wzc. Required for the extracellular polysaccharide colanic acid synthesis, probably involved in the export of colanic acid from the cell to medium. Involved in protection of cells against contact-dependent growth inhibition (CDI), probably due to the loss of a physical impediment to cell-cell contact; Belongs to the low molecular weight phosphotyrosine protein phosphatase family (147 aa)
 
   
  0.887
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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