STRING protein interaction network
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
Your Input:
Gene Fusion
wzcColanic acid production tyrosine-protein kinase; Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium. Phosphorylates udg (720 aa)    
Predicted Functional Partners:
Colanic acid production protein-tyrosine-phosphatase; Dephosphorylates Wzc . Required for the extracellular polysaccharide colanic acid synthesis, probably involved in the export of colanic acid from the cell to medium . Involved in protection of cells against contact- dependent growth inhibition (CDI), probably due to the loss of a physical impediment to cell-cell contact
Outer membrane polysaccharide export protein wza; Probably involved in the export of the extracellular polysaccharide colanic acid from the cell to medium
Putative colanic acid biosysnthesis udp-glucose lipid carrier transferase; Is the initiating enzyme for colanic acid (CA) synthesis. Catalyzes the transfer of the glucose-1-phosphate moiety from UDP-Glc onto the carrier lipid undecaprenyl phosphate (C55-P), forming a phosphoanhydride bond yielding to glucosyl-pyrophosphoryl-undecaprenol (Glc-PP-C55). Also possesses a weak galactose-1-P transferase activity
Nadh:ubiquinone oxidoreductase, fused cd subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M-antigen undecaprenyl disphosphate flippase; Belongs to the polysaccharide synthase family
Putative colanic acid biosynthesis glycosyl transferase WcaA; Putative regulator; Protein involved in colanic acid biosynthetic process
O-antigen capsule forming protein-tyrosine-phosphatase; Dephosphorylates etk
Putative o-antigen capsule outer membrane auxillary protein export channel; May be involved in polysaccharide transport
Polyisoprenol-linked o-antigen repeat unit flippase; May be involved in the translocation process of the nascent O-polysaccharide molecules and/or its ligation to lipid A core units
Mannose-1-phosphate guanylyltransferase; Involved in the biosynthesis of the capsular polysaccharide colanic acid
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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