STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mdtBMultidrug efflux system, subunit B; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function. (1040 aa)    
Predicted Functional Partners:
spy
Periplasmic ATP-independent protein refolding chaperone, stress-induced; An ATP-independent periplasmic chaperone, decreases protein aggregation and helps protein refolding. Binds substrate over a large region of its convex inner surface. Substrate protein folds while it is bound to chaperone. Increasing Spy flexibility increases its substrate affinity and overall chaperone activity (shown for 3 different substrates). Protects proteins in vitro against tannin inactivation; tannins have antimicrobial activity. Overexpression enhances the stability of otherwise unstable periplasmic prote [...]
   
  
 0.999
mdtA
Multidrug efflux system, subunit A; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function. Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 0.999
mdtC
Multidrug efflux system, subunit C; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function.
 
0.999
baeS
Sensory histidine kinase in two-component regulatory system with BaeR; Member of the two-component regulatory system BaeS/BaeR which responds to envelope stress. Activates expression of periplasmic chaperone spy in response to spheroplast formation, indole and P pili protein PapG overexpression. Activates BaeR by phosphorylation which then activates the mdtABCD and probably the CRISPR-Cas casABCDE-ygbT-ygbF operons.
  
  
 0.997
iceT
Putative citrate/iron-citrate/zinc-citrate efflux transporter; Putative transport protein; Belongs to the major facilitator superfamily. TCR/Tet family.
 
 
 0.990
tolC
Transport channel; Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells.
  
 0.980
baeR
Response regulator in two-component regulatory system with BaeS; Member of the two-component regulatory system BaeS/BaeR which responds to envelope stress. Activates expression of periplasmic chaperone spy in response to spheroplast formation, indole and P pili protein PapG overexpression. Activates the mdtABCD and probably the CRISPR-Cas casABCDE-ygbT-ygbF operon.
  
  
 0.971
acrA
Multidrug efflux system; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm.
 0.951
acrD
Aminoglycoside/multidrug efflux system; Participates in the efflux of aminoglycosides. Confers resistance to a variety of these substances. Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
  
 
0.940
emrA
Multidrug efflux system; Part of the tripartite efflux system EmrAB-TolC, which confers resistance to antibiotics such as CCCP, FCCP, 2,4-dinitrophenol and nalidixic acid. EmrA is a drug-binding protein that provides a physical link between EmrB and TolC; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
  
 0.921
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.