STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
iceTPutative citrate/iron-citrate/zinc-citrate efflux transporter; Belongs to the major facilitator superfamily. TCR/Tet family (471 aa)    
Predicted Functional Partners:
mdtC
Multidrug efflux pump rnd permease subunit mdtc; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function
 
 
 0.981
mdtA
Multidrug efflux pump membrane fusion protein mdta; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function
 
 
 0.980
mdtB
Multidrug efflux pump rnd permease subunit mdtb; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function
 
 
 0.980
baeR
Member of the two-component regulatory system BaeS/BaeR which responds to envelope stress . Activates expression of periplasmic chaperone spy in response to spheroplast formation, indole and P pili protein PapG overexpression . Activates the mdtABCD and probably the CRISPR-Cas casABCDE-ygbT-ygbF operon
   
 
 0.946
baeS
Sensory histidine kinase in two-component regulatory system with baer; Member of the two-component regulatory system BaeS/BaeR which responds to envelope stress . Activates expression of periplasmic chaperone spy in response to spheroplast formation, indole and P pili protein PapG overexpression . Activates BaeR by phosphorylation which then activates the mdtABCD and probably the CRISPR-Cas casABCDE-ygbT-ygbF operons
  
 
 0.942
frvA
Fructose-like pts system eiia component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrvAB PTS system is involved in fructose transport
    
 
 0.748
fieF
Zn(2(+))/Fe(2(+))/Cd(2(+)) exporter; Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2+) in a proton-dependent manner
   
  
 0.736
yegJ
annotation not available
      
 0.641
zitB
Zn(2(+))/Cd(2(+))/Ni(2(+))/Cu(2(+)) exporter; Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc, whereas ZntA is required for growth at more toxic concentrations
   
  
 0.612
emrK
Multidrug resistance efflux pump membrane fusion protein; Part of the tripartite efflux system EmrYK-TolC, which confers resistance to various drugs
  
  
 0.564
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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