node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
baeS | yegQ | b2078 | b2081 | Sensory histidine kinase in two-component regulatory system with BaeR; Member of the two-component regulatory system BaeS/BaeR which responds to envelope stress. Activates expression of periplasmic chaperone spy in response to spheroplast formation, indole and P pili protein PapG overexpression. Activates BaeR by phosphorylation which then activates the mdtABCD and probably the CRISPR-Cas casABCDE-ygbT-ygbF operons. | Putative peptidase; Belongs to the peptidase U32 family. | 0.696 |
cmoA | cmoB | b1870 | b1871 | carboxy-SAM synthase; Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM); Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family. | tRNA (cmo5U34)-carboxymethyltransferase, carboxy-SAM-dependent; Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L- methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5- carboxymethoxyuridine (cmo5U) at position 34 in tRNAs. Can also catalyze the SAM-dependent methylation of ho5U, with much lower efficiency. | 0.999 |
cmoA | ydcP | b1870 | b1435 | carboxy-SAM synthase; Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM); Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family. | Putative peptidase; Responsible for the formation of the 5-hydroxycytidine modification at the C2501 position (ho5C2501) of 23S rRNA. May be a Fe- S protein that catalyzes ho5C2501 formation using prephenate as a hydroxyl group donor. | 0.672 |
cmoA | yegQ | b1870 | b2081 | carboxy-SAM synthase; Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM); Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family. | Putative peptidase; Belongs to the peptidase U32 family. | 0.647 |
cmoB | cmoA | b1871 | b1870 | tRNA (cmo5U34)-carboxymethyltransferase, carboxy-SAM-dependent; Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L- methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5- carboxymethoxyuridine (cmo5U) at position 34 in tRNAs. Can also catalyze the SAM-dependent methylation of ho5U, with much lower efficiency. | carboxy-SAM synthase; Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM); Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family. | 0.999 |
cmoB | ydcP | b1871 | b1435 | tRNA (cmo5U34)-carboxymethyltransferase, carboxy-SAM-dependent; Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L- methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5- carboxymethoxyuridine (cmo5U) at position 34 in tRNAs. Can also catalyze the SAM-dependent methylation of ho5U, with much lower efficiency. | Putative peptidase; Responsible for the formation of the 5-hydroxycytidine modification at the C2501 position (ho5C2501) of 23S rRNA. May be a Fe- S protein that catalyzes ho5C2501 formation using prephenate as a hydroxyl group donor. | 0.639 |
cmoB | yegQ | b1871 | b2081 | tRNA (cmo5U34)-carboxymethyltransferase, carboxy-SAM-dependent; Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L- methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5- carboxymethoxyuridine (cmo5U) at position 34 in tRNAs. Can also catalyze the SAM-dependent methylation of ho5U, with much lower efficiency. | Putative peptidase; Belongs to the peptidase U32 family. | 0.675 |
hemN | yegQ | b3867 | b2081 | Coproporphyrinogen III oxidase, SAM and NAD(P)H dependent, oxygen-independent; Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX. It can use NAD or NADP, but NAD is preferred. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Putative peptidase; Belongs to the peptidase U32 family. | 0.585 |
ttcA | yegQ | b1344 | b2081 | tRNA s(2)C32 thioltransferase, iron sulfur cluster protein; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. Belongs to the TtcA family. | Putative peptidase; Belongs to the peptidase U32 family. | 0.645 |
yceA | yegQ | b1055 | b2081 | Putative rhodanese-related sulfurtransferase; Protein involved in cell cycle; Belongs to the UPF0176 family. | Putative peptidase; Belongs to the peptidase U32 family. | 0.521 |
ydcP | cmoA | b1435 | b1870 | Putative peptidase; Responsible for the formation of the 5-hydroxycytidine modification at the C2501 position (ho5C2501) of 23S rRNA. May be a Fe- S protein that catalyzes ho5C2501 formation using prephenate as a hydroxyl group donor. | carboxy-SAM synthase; Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM); Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family. | 0.672 |
ydcP | cmoB | b1435 | b1871 | Putative peptidase; Responsible for the formation of the 5-hydroxycytidine modification at the C2501 position (ho5C2501) of 23S rRNA. May be a Fe- S protein that catalyzes ho5C2501 formation using prephenate as a hydroxyl group donor. | tRNA (cmo5U34)-carboxymethyltransferase, carboxy-SAM-dependent; Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L- methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5- carboxymethoxyuridine (cmo5U) at position 34 in tRNAs. Can also catalyze the SAM-dependent methylation of ho5U, with much lower efficiency. | 0.639 |
ydcP | yegQ | b1435 | b2081 | Putative peptidase; Responsible for the formation of the 5-hydroxycytidine modification at the C2501 position (ho5C2501) of 23S rRNA. May be a Fe- S protein that catalyzes ho5C2501 formation using prephenate as a hydroxyl group donor. | Putative peptidase; Belongs to the peptidase U32 family. | 0.530 |
ydcP | yfhL | b1435 | b2562 | Putative peptidase; Responsible for the formation of the 5-hydroxycytidine modification at the C2501 position (ho5C2501) of 23S rRNA. May be a Fe- S protein that catalyzes ho5C2501 formation using prephenate as a hydroxyl group donor. | Putative 4Fe-4S cluster-containing protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. | 0.519 |
ydcP | yhbT | b1435 | b3157 | Putative peptidase; Responsible for the formation of the 5-hydroxycytidine modification at the C2501 position (ho5C2501) of 23S rRNA. May be a Fe- S protein that catalyzes ho5C2501 formation using prephenate as a hydroxyl group donor. | SCP-2 sterol transfer family protein; Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Likely functions as an accessory factor. | 0.434 |
ydcP | yhbV | b1435 | b3159 | Putative peptidase; Responsible for the formation of the 5-hydroxycytidine modification at the C2501 position (ho5C2501) of 23S rRNA. May be a Fe- S protein that catalyzes ho5C2501 formation using prephenate as a hydroxyl group donor. | U32 peptidase family protein; Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiU, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway. | 0.943 |
yegQ | baeS | b2081 | b2078 | Putative peptidase; Belongs to the peptidase U32 family. | Sensory histidine kinase in two-component regulatory system with BaeR; Member of the two-component regulatory system BaeS/BaeR which responds to envelope stress. Activates expression of periplasmic chaperone spy in response to spheroplast formation, indole and P pili protein PapG overexpression. Activates BaeR by phosphorylation which then activates the mdtABCD and probably the CRISPR-Cas casABCDE-ygbT-ygbF operons. | 0.696 |
yegQ | cmoA | b2081 | b1870 | Putative peptidase; Belongs to the peptidase U32 family. | carboxy-SAM synthase; Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM); Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family. | 0.647 |
yegQ | cmoB | b2081 | b1871 | Putative peptidase; Belongs to the peptidase U32 family. | tRNA (cmo5U34)-carboxymethyltransferase, carboxy-SAM-dependent; Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L- methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5- carboxymethoxyuridine (cmo5U) at position 34 in tRNAs. Can also catalyze the SAM-dependent methylation of ho5U, with much lower efficiency. | 0.675 |
yegQ | hemN | b2081 | b3867 | Putative peptidase; Belongs to the peptidase U32 family. | Coproporphyrinogen III oxidase, SAM and NAD(P)H dependent, oxygen-independent; Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX. It can use NAD or NADP, but NAD is preferred. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.585 |