node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
thiC | thiD | b3994 | b2103 | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. | Hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine. Belongs to the ThiD family. | 0.999 |
thiC | thiE | b3994 | b3993 | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. | Thiamine phosphate synthase (thiamine phosphate pyrophosphorylase); Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.999 |
thiC | thiF | b3994 | b3992 | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. | Adenylyltransferase, modifies ThiS C-terminus; Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein ThiS; Belongs to the HesA/MoeB/ThiF family. | 0.999 |
thiC | thiG | b3994 | b3991 | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. | Thiamine biosynthesis ThiGH complex subunit; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S; Belongs to the ThiG family. | 0.999 |
thiC | thiH | b3994 | b3990 | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. | Tyrosine lyase, involved in thiamine-thiazole moiety synthesis; Catalyzes the radical-mediated cleavage of tyrosine to 2- iminoacetate and 4-cresol. | 0.999 |
thiC | thiI | b3994 | b0423 | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. | tRNA s(4)U8 sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. Belongs to the ThiI family. | 0.850 |
thiC | thiL | b3994 | b0417 | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. | Thiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1. Cannot use thiamine as substrate. Is highly specific for ATP as phosphate donor; Belongs to the thiamine-monophosphate kinase family. | 0.861 |
thiC | thiM | b3994 | b2104 | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. | Hydoxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. | 0.961 |
thiC | thiS | b3994 | b4407 | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. | Immediate sulfur donor in thiazole formation; Is the sulfur donor in the synthesis of the thiazole phosphate moiety of thiamine phosphate. | 0.991 |
thiD | thiC | b2103 | b3994 | Hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine. Belongs to the ThiD family. | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. | 0.999 |
thiD | thiE | b2103 | b3993 | Hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine. Belongs to the ThiD family. | Thiamine phosphate synthase (thiamine phosphate pyrophosphorylase); Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.999 |
thiD | thiF | b2103 | b3992 | Hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine. Belongs to the ThiD family. | Adenylyltransferase, modifies ThiS C-terminus; Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein ThiS; Belongs to the HesA/MoeB/ThiF family. | 0.976 |
thiD | thiG | b2103 | b3991 | Hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine. Belongs to the ThiD family. | Thiamine biosynthesis ThiGH complex subunit; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S; Belongs to the ThiG family. | 0.987 |
thiD | thiH | b2103 | b3990 | Hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine. Belongs to the ThiD family. | Tyrosine lyase, involved in thiamine-thiazole moiety synthesis; Catalyzes the radical-mediated cleavage of tyrosine to 2- iminoacetate and 4-cresol. | 0.963 |
thiD | thiI | b2103 | b0423 | Hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine. Belongs to the ThiD family. | tRNA s(4)U8 sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. Belongs to the ThiI family. | 0.871 |
thiD | thiL | b2103 | b0417 | Hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine. Belongs to the ThiD family. | Thiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1. Cannot use thiamine as substrate. Is highly specific for ATP as phosphate donor; Belongs to the thiamine-monophosphate kinase family. | 0.933 |
thiD | thiM | b2103 | b2104 | Hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine. Belongs to the ThiD family. | Hydoxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. | 0.999 |
thiD | thiS | b2103 | b4407 | Hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine. Belongs to the ThiD family. | Immediate sulfur donor in thiazole formation; Is the sulfur donor in the synthesis of the thiazole phosphate moiety of thiamine phosphate. | 0.881 |
thiD | yegW | b2103 | b2101 | Hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine. Belongs to the ThiD family. | Putative transcriptional regulator; Protein involved in transcription repressor activity and transcription. | 0.807 |
thiE | thiC | b3993 | b3994 | Thiamine phosphate synthase (thiamine phosphate pyrophosphorylase); Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. | 0.999 |