| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cdd | cpdB | b2143 | b4213 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | 2’,3’-cyclic-nucleotide 2’-phosphodiesterase/3’-nucleotidase; This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2’,3’- cyclic nucleotide to a 3’-nucleotide and then the 3’-nucleotide to the corresponding nucleoside and phosphate; Belongs to the 5’-nucleotidase family | 0.924 |
| cdd | deoA | b2143 | b4382 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | Thymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis; Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family | 0.968 |
| cdd | deoD | b2143 | b4384 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | Purine nucleoside phosphorylase DeoD-type; Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules | 0.938 |
| cdd | rihA | b2143 | b0651 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | Pyrimidine-specific ribonucleoside hydrolase RihA; Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively | 0.917 |
| cdd | rihB | b2143 | b2162 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | Pyrimidine-specific ribonucleoside hydrolase RihB; Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides. Has a low but significant activity for the purine nucleoside xanthosine; Belongs to the IUNH family. RihB subfamily | 0.917 |
| cdd | tdk | b2143 | b1238 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | Thymidine kinase; Phosphorylates both thymidine and deoxyuridine | 0.935 |
| cdd | udk | b2143 | b2066 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | Uridine kinase; Protein involved in nucleobase, nucleoside and nucleotide interconversion; Belongs to the uridine kinase family | 0.983 |
| cdd | udp | b2143 | b3831 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis | 0.990 |
| cdd | ushA | b2143 | b0480 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | Protein UshA; Degradation of external UDP-glucose to uridine monophosphate and glucose-1-phosphate, which can then be used by the cell | 0.925 |
| cdd | yjjG | b2143 | b4374 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | Pyrimidine 5’-nucleotidase YjjG; Nucleotidase that shows high phosphatase activity toward non-canonical pyrimidine nucleotides and three canonical nucleoside 5’-monophosphates (UMP, dUMP, and dTMP), and very low activity against TDP, IMP, UDP, GMP, dGMP, AMP, dAMP, and 6- phosphogluconate. Appears to function as a house-cleaning nucleotidase in vivo, since the general nucleotidase activity of YjjG allows it to protect cells against non-canonical pyrimidine derivatives such as 5-fluoro-2’-deoxyuridine, 5-fluorouridine, 5- fluoroorotate, 5-fluorouracil, and 5-aza-2’-deoxycytidine, and pr [...] | 0.921 |
| cpdB | cdd | b4213 | b2143 | 2’,3’-cyclic-nucleotide 2’-phosphodiesterase/3’-nucleotidase; This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2’,3’- cyclic nucleotide to a 3’-nucleotide and then the 3’-nucleotide to the corresponding nucleoside and phosphate; Belongs to the 5’-nucleotidase family | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | 0.924 |
| cpdB | deoD | b4213 | b4384 | 2’,3’-cyclic-nucleotide 2’-phosphodiesterase/3’-nucleotidase; This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2’,3’- cyclic nucleotide to a 3’-nucleotide and then the 3’-nucleotide to the corresponding nucleoside and phosphate; Belongs to the 5’-nucleotidase family | Purine nucleoside phosphorylase DeoD-type; Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules | 0.921 |
| cpdB | rihB | b4213 | b2162 | 2’,3’-cyclic-nucleotide 2’-phosphodiesterase/3’-nucleotidase; This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2’,3’- cyclic nucleotide to a 3’-nucleotide and then the 3’-nucleotide to the corresponding nucleoside and phosphate; Belongs to the 5’-nucleotidase family | Pyrimidine-specific ribonucleoside hydrolase RihB; Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides. Has a low but significant activity for the purine nucleoside xanthosine; Belongs to the IUNH family. RihB subfamily | 0.916 |
| cpdB | tdk | b4213 | b1238 | 2’,3’-cyclic-nucleotide 2’-phosphodiesterase/3’-nucleotidase; This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2’,3’- cyclic nucleotide to a 3’-nucleotide and then the 3’-nucleotide to the corresponding nucleoside and phosphate; Belongs to the 5’-nucleotidase family | Thymidine kinase; Phosphorylates both thymidine and deoxyuridine | 0.425 |
| cpdB | udk | b4213 | b2066 | 2’,3’-cyclic-nucleotide 2’-phosphodiesterase/3’-nucleotidase; This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2’,3’- cyclic nucleotide to a 3’-nucleotide and then the 3’-nucleotide to the corresponding nucleoside and phosphate; Belongs to the 5’-nucleotidase family | Uridine kinase; Protein involved in nucleobase, nucleoside and nucleotide interconversion; Belongs to the uridine kinase family | 0.917 |
| cpdB | udp | b4213 | b3831 | 2’,3’-cyclic-nucleotide 2’-phosphodiesterase/3’-nucleotidase; This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2’,3’- cyclic nucleotide to a 3’-nucleotide and then the 3’-nucleotide to the corresponding nucleoside and phosphate; Belongs to the 5’-nucleotidase family | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis | 0.928 |
| cpdB | ushA | b4213 | b0480 | 2’,3’-cyclic-nucleotide 2’-phosphodiesterase/3’-nucleotidase; This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2’,3’- cyclic nucleotide to a 3’-nucleotide and then the 3’-nucleotide to the corresponding nucleoside and phosphate; Belongs to the 5’-nucleotidase family | Protein UshA; Degradation of external UDP-glucose to uridine monophosphate and glucose-1-phosphate, which can then be used by the cell | 0.942 |
| cpdB | yjjG | b4213 | b4374 | 2’,3’-cyclic-nucleotide 2’-phosphodiesterase/3’-nucleotidase; This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2’,3’- cyclic nucleotide to a 3’-nucleotide and then the 3’-nucleotide to the corresponding nucleoside and phosphate; Belongs to the 5’-nucleotidase family | Pyrimidine 5’-nucleotidase YjjG; Nucleotidase that shows high phosphatase activity toward non-canonical pyrimidine nucleotides and three canonical nucleoside 5’-monophosphates (UMP, dUMP, and dTMP), and very low activity against TDP, IMP, UDP, GMP, dGMP, AMP, dAMP, and 6- phosphogluconate. Appears to function as a house-cleaning nucleotidase in vivo, since the general nucleotidase activity of YjjG allows it to protect cells against non-canonical pyrimidine derivatives such as 5-fluoro-2’-deoxyuridine, 5-fluorouridine, 5- fluoroorotate, 5-fluorouracil, and 5-aza-2’-deoxycytidine, and pr [...] | 0.933 |
| deoA | cdd | b4382 | b2143 | Thymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis; Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | 0.968 |
| deoA | deoD | b4382 | b4384 | Thymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis; Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family | Purine nucleoside phosphorylase DeoD-type; Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules | 0.983 |
