STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
galSHTH-type transcriptional regulator GalS; Repressor of the mgl operon. Binds galactose and D- fucose as inducers. GalS binds to an operator DNA sequence within its own coding sequence (corresponding to residues 15 to 20) (346 aa)    
Predicted Functional Partners:
galR
HTH-type transcriptional regulator GalR; Repressor of the galactose operon. Binds galactose as an inducer
  
 
 
0.906
mglA
Galactose/methyl galactoside import ATP-binding protein MglA; Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system (Probable)
  
    0.835
mglB
D-galactose-binding periplasmic protein; This protein is involved in the active transport of galactose and glucose. It plays a role in the chemotaxis towards the two sugars by interacting with the trg chemoreceptor
  
 
 0.821
uxuR
Uxu operon transcriptional regulator; Repressor for the uxuRBA operon
  
 
 
 0.760
galP
Galactose-proton symporter; Uptake of galactose across the boundary membrane with the concomitant transport of protons into the cell (symport system)
     
 0.752
mlc
Protein mlc; Transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. Regulates the expression of malT
      
 0.751
dgoR
Galactonate operon transcriptional repressor; Repressor for the dgoRKAT operon. Binds D-galactonate as an inducer
    
 
 0.701
ydiP
Uncharacterized HTH-type transcriptional regulator YdiP; Putative ARAC-type regulatory protein; Protein involved in transcription and regulation of transcription, DNA-dependent
      
 0.688
frvB
Fructose-like PTS system EIIBC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrvAB PTS system is involved in fructose transport
     
 0.620
malT
HTH-type transcriptional regulator MalT; Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Binds and recognizes a DNA motif (called the malT box): 5'-GGA[TG]GA-3'
   
  
 0.609
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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