STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yeiLCrp/fnr family transcriptional regulator, putaive post-exponential-phase nitrogen-starvation regulator; Transcription regulator involved in mid-term, stationary- phase viability under nitrogen starvation. Might control expression of the salvage pathways or in some other way repress the recycling of nucleobases to nucleic acids and enhance their use as general nitrogen sources during nitrogen-limited growth (219 aa)    
Predicted Functional Partners:
rihB
Pyrimidine-specific ribonucleoside hydrolase rihb; Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides. Has a low but significant activity for the purine nucleoside xanthosine
 
  
 0.842
yegK
Protein-serine/threonine phosphatase pphc; PP2C-like phosphatase that can dephosphorylate YegI. In vitro, can hydrolyze p-nitrophenyl phosphate (pNPP) to p-nitrophenol
  
 0.755
yegI
Protein kinase-related putative non-specific dna-binding protein; Probable serine/threonine kinase
  
    0.666
gltB
Glutamate synthase (nadph) large chain; Catalyzes the conversion of L-glutamine and 2-oxoglutarate into two molecules of L-glutamate
  
  
 0.655
yifE
Macrodomain ori protein; Belongs to the UPF0438 family
      
 0.640
evgS
Hybrid sensory histidine kinase in two-component regulatory system with evga; Member of the two-component regulatory system EvgS/EvgA. Phosphorylates EvgA via a four-step phosphorelay in response to environmental signals
 
 
 0.636
yddB
Putative tonb-dependent outer membrane receptor; To H.influenzae HI_1369
  
   
 0.627
pqqL
Putative periplasmic m16 family zinc metalloendopeptidase; Putative zinc protease
  
     0.617
yegE
Putative diguanylate cyclase dgce; Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules (By similarity). Involved in the control of the switch from cell motility to adhesion via regulation of cellular levels of c-di-GMP (Probable). Part of a signaling cascade that regulates curli biosynthesis. The cascade is composed of two c-di- GMP control modules, in which c-di-GMP controlled by the DgcE/PdeH pair (module I) regulates the activity of the DgcM/PdeR pair (module II), which in turn regulates activity of the transcription factor MlrA and expression [...]
    
 
 0.610
yihF
Uncharacterized protein yihf; To E.coli YdgA and H.influenzae HI_1236
  
     0.585
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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