node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ccmA | ccmB | b2201 | b2200 | Heme trafficking system atp-binding protein; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system | Heme trafficking system membrane protein ccmb; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes | 0.999 |
ccmA | ccmC | b2201 | b2199 | Heme trafficking system atp-binding protein; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system | Heme trafficking system membrane protein ccmc; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes | 0.999 |
ccmA | ccmD | b2201 | b2198 | Heme trafficking system atp-binding protein; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system | Heme trafficking system membrane protein ccmd; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes | 0.997 |
ccmA | ccmE | b2201 | b2197 | Heme trafficking system atp-binding protein; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system | Cytochrome c-type biogenesis protein ccme; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH | 0.999 |
ccmA | ccmF | b2201 | b2196 | Heme trafficking system atp-binding protein; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system | Holocytochrome c synthetase membrane subunit ccmf; Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase | 0.995 |
ccmA | ccmH | b2201 | b2194 | Heme trafficking system atp-binding protein; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system | Holocytochrome c synthetase - thiol:disulfide oxidoreductase ccmh; May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase | 0.995 |
ccmA | dsbE | b2201 | b2195 | Heme trafficking system atp-binding protein; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system | Cytochrome c biogenesis protein ccmg, thiol:disulfide interchange protein dsbe; Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase. DsbE is maintained in a reduced state by DsbD | 0.995 |
ccmA | napD | b2201 | b2207 | Heme trafficking system atp-binding protein; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system | Assembly protein for periplasmic nitrate reductase; Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin- arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export May have a role in the insertion of the NapA molybdenum cofactor | 0.901 |
ccmA | nrfE | b2201 | b4074 | Heme trafficking system atp-binding protein; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system | Heme lyase (nrfefg) for insertion of heme into c552, subunit nrfe; May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase | 0.817 |
ccmA | nrfG | b2201 | b4076 | Heme trafficking system atp-binding protein; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system | Heme lyase (nrfefg) for insertion of heme into c552, subunit nrfg; Required for formate-dependent nitrite reduction. Not required for the biosynthesis of any of the c-type cytochromes nor for the secretion of the periplasmic cytochromes | 0.706 |
ccmB | ccmA | b2200 | b2201 | Heme trafficking system membrane protein ccmb; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes | Heme trafficking system atp-binding protein; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system | 0.999 |
ccmB | ccmC | b2200 | b2199 | Heme trafficking system membrane protein ccmb; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes | Heme trafficking system membrane protein ccmc; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes | 0.999 |
ccmB | ccmD | b2200 | b2198 | Heme trafficking system membrane protein ccmb; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes | Heme trafficking system membrane protein ccmd; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes | 0.997 |
ccmB | ccmE | b2200 | b2197 | Heme trafficking system membrane protein ccmb; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes | Cytochrome c-type biogenesis protein ccme; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH | 0.999 |
ccmB | ccmF | b2200 | b2196 | Heme trafficking system membrane protein ccmb; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes | Holocytochrome c synthetase membrane subunit ccmf; Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase | 0.997 |
ccmB | ccmH | b2200 | b2194 | Heme trafficking system membrane protein ccmb; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes | Holocytochrome c synthetase - thiol:disulfide oxidoreductase ccmh; May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase | 0.996 |
ccmB | dsbE | b2200 | b2195 | Heme trafficking system membrane protein ccmb; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes | Cytochrome c biogenesis protein ccmg, thiol:disulfide interchange protein dsbe; Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase. DsbE is maintained in a reduced state by DsbD | 0.993 |
ccmB | napD | b2200 | b2207 | Heme trafficking system membrane protein ccmb; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes | Assembly protein for periplasmic nitrate reductase; Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin- arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export May have a role in the insertion of the NapA molybdenum cofactor | 0.897 |
ccmB | nrfE | b2200 | b4074 | Heme trafficking system membrane protein ccmb; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes | Heme lyase (nrfefg) for insertion of heme into c552, subunit nrfe; May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase | 0.862 |
ccmB | nrfG | b2200 | b4076 | Heme trafficking system membrane protein ccmb; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes | Heme lyase (nrfefg) for insertion of heme into c552, subunit nrfg; Required for formate-dependent nitrite reduction. Not required for the biosynthesis of any of the c-type cytochromes nor for the secretion of the periplasmic cytochromes | 0.664 |