node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ahpC | dsbE | b0605 | b2195 | Alkyl hydroperoxide reductase, C22 subunit; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Is the primary scavenger for endogenously generated hydrogen peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. | Periplasmic thioredoxin of cytochrome c-type biogenesis; Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase. DsbE is maintained in a reduced state by DsbD. | 0.952 |
ccmA | ccmB | b2201 | b2200 | Heme export ABC transporter ATPase; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system. | Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. | 0.999 |
ccmA | ccmC | b2201 | b2199 | Heme export ABC transporter ATPase; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system. | Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. | 0.999 |
ccmA | ccmD | b2201 | b2198 | Heme export ABC transporter ATPase; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system. | Cytochrome c biogenesis protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. | 0.999 |
ccmA | ccmE | b2201 | b2197 | Heme export ABC transporter ATPase; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system. | Periplasmic heme chaperone; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH; Belongs to the CcmE/CycJ family. | 0.998 |
ccmA | ccmF | b2201 | b2196 | Heme export ABC transporter ATPase; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system. | Heme lyase, CcmF subunit; Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase. | 0.992 |
ccmA | ccmH | b2201 | b2194 | Heme export ABC transporter ATPase; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system. | Heme lyase, CcmH subunit; May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase. | 0.991 |
ccmA | dsbA | b2201 | b3860 | Heme export ABC transporter ATPase; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system. | Periplasmic protein disulfide isomerase I; Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. Required for pilus biogenesis. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway. Belongs to the thioredoxin family. DsbA subfamily. | 0.608 |
ccmA | dsbD | b2201 | b4136 | Heme export ABC transporter ATPase; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system. | Thiol:disulfide interchange protein and activator of DsbC; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm, thereby maintaining the active site of DsbC, DsbE and DsbG in a reduced state. This transfer involves a cascade of disulfide bond formation and reduction steps; Belongs to the thioredoxin family. DsbD subfamily. | 0.750 |
ccmA | dsbE | b2201 | b2195 | Heme export ABC transporter ATPase; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system. | Periplasmic thioredoxin of cytochrome c-type biogenesis; Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase. DsbE is maintained in a reduced state by DsbD. | 0.989 |
ccmB | ccmA | b2200 | b2201 | Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. | Heme export ABC transporter ATPase; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system. | 0.999 |
ccmB | ccmC | b2200 | b2199 | Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. | Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. | 0.999 |
ccmB | ccmD | b2200 | b2198 | Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. | Cytochrome c biogenesis protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. | 0.999 |
ccmB | ccmE | b2200 | b2197 | Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. | Periplasmic heme chaperone; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH; Belongs to the CcmE/CycJ family. | 0.999 |
ccmB | ccmF | b2200 | b2196 | Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. | Heme lyase, CcmF subunit; Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase. | 0.993 |
ccmB | ccmH | b2200 | b2194 | Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. | Heme lyase, CcmH subunit; May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase. | 0.966 |
ccmB | dsbE | b2200 | b2195 | Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. | Periplasmic thioredoxin of cytochrome c-type biogenesis; Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase. DsbE is maintained in a reduced state by DsbD. | 0.985 |
ccmC | ccmA | b2199 | b2201 | Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. | Heme export ABC transporter ATPase; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system. | 0.999 |
ccmC | ccmB | b2199 | b2200 | Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. | Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. | 0.999 |
ccmC | ccmD | b2199 | b2198 | Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. | Cytochrome c biogenesis protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. | 0.999 |