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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
napHFerredoxin-type protein naph; Required for electron transfer from ubiquinol, via NapC, to the periplasmic nitrate reductase NapAB complex (287 aa)    
Predicted Functional Partners:
napB
Nitrate reductase, small, cytochrome c550 subunit, periplasmic; Electron transfer subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from the membrane-anchored tetraheme c-type NapC protein and transfers these to NapA subunit, thus allowing electron flow between membrane and periplasm. Essential for periplasmic nitrate reduction with nitrate as the terminal electron acceptor
 
 
 0.999
napG
Ferredoxin-type protein napg; Required for electron transfer from ubiquinol, via NapC, to the periplasmic nitrate reductase NapAB complex
 
 0.999
napA
Nitrate reductase, periplasmic, large subunit; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite
 
 
 0.999
napC
Periplasmic nitrate reductase cytochrome c protein; Mediates electron flow from quinones to the NapAB complex
 
 
 0.997
napF
Ferredoxin-type protein, role in electron transfer to periplasmic nitrate reductase napa; Could be involved in the maturation of NapA, the catalytic subunit of the periplasmic nitrate reductase, before its export into the periplasm . Is not involved in the electron transfer from menaquinol or ubiquinol to the periplasmic nitrate reductase
 
  
 0.997
napD
Assembly protein for periplasmic nitrate reductase; Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin- arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export May have a role in the insertion of the NapA molybdenum cofactor
 
  
 0.996
ccmA
Heme trafficking system atp-binding protein; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system
 
    0.906
ccmB
Heme trafficking system membrane protein ccmb; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
 
  
 0.900
glpD
sn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding; Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses molecular oxygen or nitrate as electron acceptor
     
 0.900
nrfA
Nitrite reductase, formate-dependent, cytochrome; Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process Has very low activity toward hydroxylamine . Has even lower activity toward sulfite . Sulfite reductase activity is maximal at neutral pH (By similarity)
 
  
 0.892
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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