STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
atoSSensory histidine kinase in two-component regulatory system with atoc; Member of the two-component regulatory system AtoS/AtoC. In the presence of acetoacetate, AtoS/AtoC stimulates the expression of the atoDAEB operon, leading to short chain fatty acid catabolism and activation of the poly-(R)-3-hydroxybutyrate (cPHB) biosynthetic pathway. Also induces the operon in response to spermidine . Involved in the regulation of motility and chemotaxis, via transcriptional induction of the flagellar regulon . AtoS is a membrane-associated kinase that phosphorylates and activates AtoC in respon [...] (608 aa)    
Predicted Functional Partners:
atoC
Dna-binding transcriptional activator/ornithine decarboxylase inhibitor atoc; Member of the two-component regulatory system AtoS/AtoC. In the presence of acetoacetate, AtoS/AtoC stimulates the expression of the atoDAEB operon, leading to short chain fatty acid catabolism and activation of the poly-(R)-3-hydroxybutyrate (cPHB) biosynthetic pathway. Also induces the operon in response to spermidine . Involved in the regulation of motility and chemotaxis, via transcriptional induction of the flagellar regulon . AtoC acts by binding directly to the promoter region of the target genes . In [...]
 0.999
atoE
Short-chain fatty acids transporter; May be responsible for the uptake of short-chain fatty acids
 
    0.780
atoA
Acetate coa/acetoacetate coa-transferase beta subunit; Belongs to the 3-oxoacid CoA-transferase subunit B family
 
   
 0.749
atoD
Acetate coa/acetoacetate coa-transferase alpha subunit; acetyl-CoA:acetoacetyl-CoA transferase alpha subunit; Protein involved in fatty acid oxidation
 
  
 0.710
yegE
Putative diguanylate cyclase dgce; Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules (By similarity). Involved in the control of the switch from cell motility to adhesion via regulation of cellular levels of c-di-GMP (Probable). Part of a signaling cascade that regulates curli biosynthesis. The cascade is composed of two c-di- GMP control modules, in which c-di-GMP controlled by the DgcE/PdeH pair (module I) regulates the activity of the DgcM/PdeR pair (module II), which in turn regulates activity of the transcription factor MlrA and expression [...]
 
 
 
 0.694
rcsC
Two-component system, narl family, capsular synthesis sensor histidine kinase rcsc; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. RcsC has also phosphatase activity. The system controls expression of genes involved in colanic acid capsule synthesis, biofilm formation and cell division
   
 
0.627
gltB
Glutamate synthase (nadph) large chain; Catalyzes the conversion of L-glutamine and 2-oxoglutarate into two molecules of L-glutamate
  
  
 0.575
nohD
Terminase small subunit / prophage dna-packing protein; DNA-packaging protein NU1 homolog; Bacteriophage DNA packaging protein
  
     0.498
dosP
Oxygen sensor, c-di-gmp phosphodiesterase, heme-regulated; Heme-based oxygen sensor protein displaying phosphodiesterase (PDE) activity toward c-di-GMP in response to oxygen availability. Involved in the modulation of intracellular c-di-GMP levels, in association with DosC which catalyzes the biosynthesis of c-di-GMP (diguanylate cyclase activity). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. Has very poor PDE activity on cAMP but is not active with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate . Via its PDE activity on [...]
 
 
 0.493
yjiK
Uncharacterized protein YjiK; Putative enzyme; Not classified
  
     0.482
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
Server load: low (6%) [HD]