node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
adhE | atoA | b1241 | b2222 | Acetaldehyde dehydrogenase [acetylating]; This enzyme has three activities: ADH, ACDH, and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent reaction; In the N-terminal section; belongs to the aldehyde dehydrogenase family. | acetyl-CoA:acetoacetyl-CoA transferase beta subunit; Protein involved in fatty acid oxidation; Belongs to the 3-oxoacid CoA-transferase subunit B family. | 0.945 |
adhE | atoB | b1241 | b2224 | Acetaldehyde dehydrogenase [acetylating]; This enzyme has three activities: ADH, ACDH, and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent reaction; In the N-terminal section; belongs to the aldehyde dehydrogenase family. | acetyl-CoA acetyltransferase; Protein involved in fatty acid oxidation. | 0.982 |
adhE | atoD | b1241 | b2221 | Acetaldehyde dehydrogenase [acetylating]; This enzyme has three activities: ADH, ACDH, and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent reaction; In the N-terminal section; belongs to the aldehyde dehydrogenase family. | acetyl-CoA:acetoacetyl-CoA transferase alpha subunit; Protein involved in fatty acid oxidation. | 0.957 |
adhE | fadB | b1241 | b3846 | Acetaldehyde dehydrogenase [acetylating]; This enzyme has three activities: ADH, ACDH, and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent reaction; In the N-terminal section; belongs to the aldehyde dehydrogenase family. | Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. | 0.629 |
adhE | fadJ | b1241 | b2341 | Acetaldehyde dehydrogenase [acetylating]; This enzyme has three activities: ADH, ACDH, and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent reaction; In the N-terminal section; belongs to the aldehyde dehydrogenase family. | enoyl-CoA hydratase/epimerase and isomerase/3-hydroxyacyl-CoA dehydrogenase; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities. Strongly involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate and weakly involved in the aerobic degradation of long-chain fatty acids; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. | 0.578 |
adhE | mhpF | b1241 | b0351 | Acetaldehyde dehydrogenase [acetylating]; This enzyme has three activities: ADH, ACDH, and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent reaction; In the N-terminal section; belongs to the aldehyde dehydrogenase family. | acetaldehyde-CoA dehydrogenase II, NAD-binding; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of 3-phenylpropanoate. Functions as a chaperone protein for folding of MhpE. | 0.990 |
adhE | ydiF | b1241 | b1694 | Acetaldehyde dehydrogenase [acetylating]; This enzyme has three activities: ADH, ACDH, and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent reaction; In the N-terminal section; belongs to the aldehyde dehydrogenase family. | Putative acetyl-CoA:acetoacetyl-CoA transferase: alpha subunit/beta subunit; CoA transferase having broad substrate specificity for short- chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. May play a role in short-chain fatty acid metabolism in E.coli (By similarity). Belongs to the 3-oxoacid CoA-transferase family. | 0.912 |
adhE | yqeF | b1241 | b2844 | Acetaldehyde dehydrogenase [acetylating]; This enzyme has three activities: ADH, ACDH, and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent reaction; In the N-terminal section; belongs to the aldehyde dehydrogenase family. | Short chain acyltransferase; Putative acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.933 |
atoA | adhE | b2222 | b1241 | acetyl-CoA:acetoacetyl-CoA transferase beta subunit; Protein involved in fatty acid oxidation; Belongs to the 3-oxoacid CoA-transferase subunit B family. | Acetaldehyde dehydrogenase [acetylating]; This enzyme has three activities: ADH, ACDH, and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent reaction; In the N-terminal section; belongs to the aldehyde dehydrogenase family. | 0.945 |
atoA | atoB | b2222 | b2224 | acetyl-CoA:acetoacetyl-CoA transferase beta subunit; Protein involved in fatty acid oxidation; Belongs to the 3-oxoacid CoA-transferase subunit B family. | acetyl-CoA acetyltransferase; Protein involved in fatty acid oxidation. | 0.995 |
atoA | atoC | b2222 | b2220 | acetyl-CoA:acetoacetyl-CoA transferase beta subunit; Protein involved in fatty acid oxidation; Belongs to the 3-oxoacid CoA-transferase subunit B family. | Regulatory protein AtoC; Member of the two-component regulatory system AtoS/AtoC. In the presence of acetoacetate, AtoS/AtoC stimulates the expression of the atoDAEB operon, leading to short chain fatty acid catabolism and activation of the poly-(R)-3-hydroxybutyrate (cPHB) biosynthetic pathway. Also induces the operon in response to spermidine. Involved in the regulation of motility and chemotaxis, via transcriptional induction of the flagellar regulon. AtoC acts by binding directly to the promoter region of the target genes. In addition to its role as a transcriptional regulator, fun [...] | 0.875 |
atoA | atoD | b2222 | b2221 | acetyl-CoA:acetoacetyl-CoA transferase beta subunit; Protein involved in fatty acid oxidation; Belongs to the 3-oxoacid CoA-transferase subunit B family. | acetyl-CoA:acetoacetyl-CoA transferase alpha subunit; Protein involved in fatty acid oxidation. | 0.999 |
atoA | atoE | b2222 | b2223 | acetyl-CoA:acetoacetyl-CoA transferase beta subunit; Protein involved in fatty acid oxidation; Belongs to the 3-oxoacid CoA-transferase subunit B family. | Short chain fatty acid transporter; May be responsible for the uptake of short-chain fatty acids. | 0.986 |
atoA | fadB | b2222 | b3846 | acetyl-CoA:acetoacetyl-CoA transferase beta subunit; Protein involved in fatty acid oxidation; Belongs to the 3-oxoacid CoA-transferase subunit B family. | Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. | 0.973 |
atoA | fadJ | b2222 | b2341 | acetyl-CoA:acetoacetyl-CoA transferase beta subunit; Protein involved in fatty acid oxidation; Belongs to the 3-oxoacid CoA-transferase subunit B family. | enoyl-CoA hydratase/epimerase and isomerase/3-hydroxyacyl-CoA dehydrogenase; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities. Strongly involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate and weakly involved in the aerobic degradation of long-chain fatty acids; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. | 0.961 |
atoA | mhpF | b2222 | b0351 | acetyl-CoA:acetoacetyl-CoA transferase beta subunit; Protein involved in fatty acid oxidation; Belongs to the 3-oxoacid CoA-transferase subunit B family. | acetaldehyde-CoA dehydrogenase II, NAD-binding; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of 3-phenylpropanoate. Functions as a chaperone protein for folding of MhpE. | 0.900 |
atoA | ydiF | b2222 | b1694 | acetyl-CoA:acetoacetyl-CoA transferase beta subunit; Protein involved in fatty acid oxidation; Belongs to the 3-oxoacid CoA-transferase subunit B family. | Putative acetyl-CoA:acetoacetyl-CoA transferase: alpha subunit/beta subunit; CoA transferase having broad substrate specificity for short- chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. May play a role in short-chain fatty acid metabolism in E.coli (By similarity). Belongs to the 3-oxoacid CoA-transferase family. | 0.963 |
atoA | yqeF | b2222 | b2844 | acetyl-CoA:acetoacetyl-CoA transferase beta subunit; Protein involved in fatty acid oxidation; Belongs to the 3-oxoacid CoA-transferase subunit B family. | Short chain acyltransferase; Putative acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.919 |
atoB | adhE | b2224 | b1241 | acetyl-CoA acetyltransferase; Protein involved in fatty acid oxidation. | Acetaldehyde dehydrogenase [acetylating]; This enzyme has three activities: ADH, ACDH, and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent reaction; In the N-terminal section; belongs to the aldehyde dehydrogenase family. | 0.982 |
atoB | atoA | b2224 | b2222 | acetyl-CoA acetyltransferase; Protein involved in fatty acid oxidation. | acetyl-CoA:acetoacetyl-CoA transferase beta subunit; Protein involved in fatty acid oxidation; Belongs to the 3-oxoacid CoA-transferase subunit B family. | 0.995 |