node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
fadK | yfaA | b1701 | b2230 | Short chain acyl-CoA synthetase, anaerobic; Catalyzes the esterification, concomitant with transport, of exogenous fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. Is maximally active on C6:0, C8:0 and C12:0 fatty acids, while has a low activity on C14-C18 chain length fatty acids. Is involved in the anaerobic beta-oxidative degradation of fatty acids, which allows anaerobic growth of E.coli on fatty acids as a sole carbon and energy source in the presence of nitrate or fumarate as a terminal electron acceptor. Can fun [...] | DUF2138 family protein, putative host defense protein. | 0.508 |
gyrA | yfaA | b2231 | b2230 | DNA gyrase (type II topoisomerase), subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state. This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli. Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes. Relaxes negatively supercoiled DNA in an ATP-independent manner. E.coli gyrase has higher supercoiling activity than many other bac [...] | DUF2138 family protein, putative host defense protein. | 0.478 |
gyrA | yfaT | b2231 | b2229 | DNA gyrase (type II topoisomerase), subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state. This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli. Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes. Relaxes negatively supercoiled DNA in an ATP-independent manner. E.coli gyrase has higher supercoiling activity than many other bac [...] | Uncharacterized protein YfaT; Pseudogene, bacterial alpha2-macroglobulin YfaS variant family; putative membrane protein; To P.aeruginosa PA4490 and T.maritima TM0986. | 0.478 |
yahF | yfaA | b0320 | b2230 | Putative NAD(P)-binding succinyl-CoA synthase; Putative oxidoreductase subunit; To E.coli FdrA and some, to bacterial SucD. | DUF2138 family protein, putative host defense protein. | 0.809 |
yfaA | fadK | b2230 | b1701 | DUF2138 family protein, putative host defense protein. | Short chain acyl-CoA synthetase, anaerobic; Catalyzes the esterification, concomitant with transport, of exogenous fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. Is maximally active on C6:0, C8:0 and C12:0 fatty acids, while has a low activity on C14-C18 chain length fatty acids. Is involved in the anaerobic beta-oxidative degradation of fatty acids, which allows anaerobic growth of E.coli on fatty acids as a sole carbon and energy source in the presence of nitrate or fumarate as a terminal electron acceptor. Can fun [...] | 0.508 |
yfaA | gyrA | b2230 | b2231 | DUF2138 family protein, putative host defense protein. | DNA gyrase (type II topoisomerase), subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state. This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli. Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes. Relaxes negatively supercoiled DNA in an ATP-independent manner. E.coli gyrase has higher supercoiling activity than many other bac [...] | 0.478 |
yfaA | yahF | b2230 | b0320 | DUF2138 family protein, putative host defense protein. | Putative NAD(P)-binding succinyl-CoA synthase; Putative oxidoreductase subunit; To E.coli FdrA and some, to bacterial SucD. | 0.809 |
yfaA | yfaP | b2230 | b2225 | DUF2138 family protein, putative host defense protein. | DUF2135 family protein, putative host defense protein. | 0.956 |
yfaA | yfaQ | b2230 | b2226 | DUF2138 family protein, putative host defense protein. | Tandem DUF2300 domain protein, putative host defense protein. | 0.935 |
yfaA | yfaT | b2230 | b2229 | DUF2138 family protein, putative host defense protein. | Uncharacterized protein YfaT; Pseudogene, bacterial alpha2-macroglobulin YfaS variant family; putative membrane protein; To P.aeruginosa PA4490 and T.maritima TM0986. | 0.986 |
yfaA | yfhM | b2230 | b2520 | DUF2138 family protein, putative host defense protein. | Bacterial alpha2-macroglobulin colonization factor ECAM; Protects the bacterial cell from host peptidases. Acts by a 'trapping' mechanism. Cleavage of the bait-region domain by host peptidases leads to a global conformational change, which results in entrapment of the host peptidase and activation of the thioester bond that covalently binds the attacking host peptidase. Trapped peptidases are still active except against very large substrates. May protect the entire periplam, including the lipoproteins anchored to the periplasmic side of the outer membrane, against intruding endopeptidases. | 0.695 |
yfaA | ynbC | b2230 | b1410 | DUF2138 family protein, putative host defense protein. | Putative esterase. | 0.436 |
yfaP | yfaA | b2225 | b2230 | DUF2135 family protein, putative host defense protein. | DUF2138 family protein, putative host defense protein. | 0.956 |
yfaP | yfaQ | b2225 | b2226 | DUF2135 family protein, putative host defense protein. | Tandem DUF2300 domain protein, putative host defense protein. | 0.987 |
yfaP | yfaT | b2225 | b2229 | DUF2135 family protein, putative host defense protein. | Uncharacterized protein YfaT; Pseudogene, bacterial alpha2-macroglobulin YfaS variant family; putative membrane protein; To P.aeruginosa PA4490 and T.maritima TM0986. | 0.882 |
yfaP | yfhM | b2225 | b2520 | DUF2135 family protein, putative host defense protein. | Bacterial alpha2-macroglobulin colonization factor ECAM; Protects the bacterial cell from host peptidases. Acts by a 'trapping' mechanism. Cleavage of the bait-region domain by host peptidases leads to a global conformational change, which results in entrapment of the host peptidase and activation of the thioester bond that covalently binds the attacking host peptidase. Trapped peptidases are still active except against very large substrates. May protect the entire periplam, including the lipoproteins anchored to the periplasmic side of the outer membrane, against intruding endopeptidases. | 0.679 |
yfaQ | yfaA | b2226 | b2230 | Tandem DUF2300 domain protein, putative host defense protein. | DUF2138 family protein, putative host defense protein. | 0.935 |
yfaQ | yfaP | b2226 | b2225 | Tandem DUF2300 domain protein, putative host defense protein. | DUF2135 family protein, putative host defense protein. | 0.987 |
yfaQ | yfaT | b2226 | b2229 | Tandem DUF2300 domain protein, putative host defense protein. | Uncharacterized protein YfaT; Pseudogene, bacterial alpha2-macroglobulin YfaS variant family; putative membrane protein; To P.aeruginosa PA4490 and T.maritima TM0986. | 0.922 |
yfaQ | yfhM | b2226 | b2520 | Tandem DUF2300 domain protein, putative host defense protein. | Bacterial alpha2-macroglobulin colonization factor ECAM; Protects the bacterial cell from host peptidases. Acts by a 'trapping' mechanism. Cleavage of the bait-region domain by host peptidases leads to a global conformational change, which results in entrapment of the host peptidase and activation of the thioester bond that covalently binds the attacking host peptidase. Trapped peptidases are still active except against very large substrates. May protect the entire periplam, including the lipoproteins anchored to the periplasmic side of the outer membrane, against intruding endopeptidases. | 0.589 |