node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
glcD | gudD | b2979 | b2787 | Glycolate oxidase subunit, FAD-linked; Component of a complex that catalyzes the oxidation of glycolate to glyoxylate. Is required for E.coli to grow on glycolate as a sole source of carbon. Is also able to oxidize D-lactate ((R)-lactate) with a similar rate. Does not link directly to O(2), and 2,6-dichloroindophenol (DCIP) and phenazine methosulfate (PMS) can act as artificial electron acceptors in vitro, but the physiological molecule that functions as primary electron acceptor during glycolate oxidation is unknown ; Belongs to the FAD-binding oxidoreductase/transferase type 4 family. | D-glucarate dehydratase 1; Catalyzes the dehydration of glucarate to 5-keto-4-deoxy-D- glucarate (5-kdGluc). Also acts on L-idarate; Belongs to the mandelate racemase/muconate lactonizing enzyme family. GlucD subfamily. | 0.457 |
glcD | rhmD | b2979 | b2247 | Glycolate oxidase subunit, FAD-linked; Component of a complex that catalyzes the oxidation of glycolate to glyoxylate. Is required for E.coli to grow on glycolate as a sole source of carbon. Is also able to oxidize D-lactate ((R)-lactate) with a similar rate. Does not link directly to O(2), and 2,6-dichloroindophenol (DCIP) and phenazine methosulfate (PMS) can act as artificial electron acceptors in vitro, but the physiological molecule that functions as primary electron acceptor during glycolate oxidation is unknown ; Belongs to the FAD-binding oxidoreductase/transferase type 4 family. | L-rhamnonate dehydratase; Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy- L-rhamnonate (KDR). Can also dehydrate L-lyxonate, L-mannonate and D- gulonate, although less efficiently, but not 2-keto-4-hydroxyheptane- 1,7-dioate; Belongs to the mandelate racemase/muconate lactonizing enzyme family. RhamD subfamily. | 0.629 |
gudD | glcD | b2787 | b2979 | D-glucarate dehydratase 1; Catalyzes the dehydration of glucarate to 5-keto-4-deoxy-D- glucarate (5-kdGluc). Also acts on L-idarate; Belongs to the mandelate racemase/muconate lactonizing enzyme family. GlucD subfamily. | Glycolate oxidase subunit, FAD-linked; Component of a complex that catalyzes the oxidation of glycolate to glyoxylate. Is required for E.coli to grow on glycolate as a sole source of carbon. Is also able to oxidize D-lactate ((R)-lactate) with a similar rate. Does not link directly to O(2), and 2,6-dichloroindophenol (DCIP) and phenazine methosulfate (PMS) can act as artificial electron acceptors in vitro, but the physiological molecule that functions as primary electron acceptor during glycolate oxidation is unknown ; Belongs to the FAD-binding oxidoreductase/transferase type 4 family. | 0.457 |
gudD | rhmD | b2787 | b2247 | D-glucarate dehydratase 1; Catalyzes the dehydration of glucarate to 5-keto-4-deoxy-D- glucarate (5-kdGluc). Also acts on L-idarate; Belongs to the mandelate racemase/muconate lactonizing enzyme family. GlucD subfamily. | L-rhamnonate dehydratase; Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy- L-rhamnonate (KDR). Can also dehydrate L-lyxonate, L-mannonate and D- gulonate, although less efficiently, but not 2-keto-4-hydroxyheptane- 1,7-dioate; Belongs to the mandelate racemase/muconate lactonizing enzyme family. RhamD subfamily. | 0.817 |
rhaA | rhaM | b3903 | b3901 | L-rhamnose isomerase; Protein involved in carbohydrate catabolic process. | L-rhamnose mutarotase; Involved in the anomeric conversion of L-rhamnose. | 0.998 |
rhaA | rhaR | b3903 | b3906 | L-rhamnose isomerase; Protein involved in carbohydrate catabolic process. | Transcriptional activator of rhaSR; Activates expression of the rhaSR operon in response to L- rhamnose. | 0.936 |
rhaA | rhmD | b3903 | b2247 | L-rhamnose isomerase; Protein involved in carbohydrate catabolic process. | L-rhamnonate dehydratase; Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy- L-rhamnonate (KDR). Can also dehydrate L-lyxonate, L-mannonate and D- gulonate, although less efficiently, but not 2-keto-4-hydroxyheptane- 1,7-dioate; Belongs to the mandelate racemase/muconate lactonizing enzyme family. RhamD subfamily. | 0.784 |
rhaM | rhaA | b3901 | b3903 | L-rhamnose mutarotase; Involved in the anomeric conversion of L-rhamnose. | L-rhamnose isomerase; Protein involved in carbohydrate catabolic process. | 0.998 |
rhaM | rhaR | b3901 | b3906 | L-rhamnose mutarotase; Involved in the anomeric conversion of L-rhamnose. | Transcriptional activator of rhaSR; Activates expression of the rhaSR operon in response to L- rhamnose. | 0.585 |
rhaM | rhmA | b3901 | b2245 | L-rhamnose mutarotase; Involved in the anomeric conversion of L-rhamnose. | 2-keto-3-deoxy-L-rhamnonate aldolase; Catalyzes the reversible retro-aldol cleavage of 2-keto-3- deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde. 2-keto-3-deoxy- L-mannonate, 2-keto-3-deoxy-L-lyxonate and 4-hydroxy-2-ketoheptane-1,7- dioate (HKHD) are also reasonably good substrates, although 2-keto-3- deoxy-L-rhamnonate is likely to be the physiological substrate. | 0.551 |
rhaM | rhmD | b3901 | b2247 | L-rhamnose mutarotase; Involved in the anomeric conversion of L-rhamnose. | L-rhamnonate dehydratase; Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy- L-rhamnonate (KDR). Can also dehydrate L-lyxonate, L-mannonate and D- gulonate, although less efficiently, but not 2-keto-4-hydroxyheptane- 1,7-dioate; Belongs to the mandelate racemase/muconate lactonizing enzyme family. RhamD subfamily. | 0.821 |
rhaM | rhmR | b3901 | b2248 | L-rhamnose mutarotase; Involved in the anomeric conversion of L-rhamnose. | Putative DNA-binding transcriptional regulator for the rhm operon; Putative regulator; Protein involved in transcription and regulation of transcription, DNA-dependent. | 0.433 |
rhaR | rhaA | b3906 | b3903 | Transcriptional activator of rhaSR; Activates expression of the rhaSR operon in response to L- rhamnose. | L-rhamnose isomerase; Protein involved in carbohydrate catabolic process. | 0.936 |
rhaR | rhaM | b3906 | b3901 | Transcriptional activator of rhaSR; Activates expression of the rhaSR operon in response to L- rhamnose. | L-rhamnose mutarotase; Involved in the anomeric conversion of L-rhamnose. | 0.585 |
rhaR | rhmD | b3906 | b2247 | Transcriptional activator of rhaSR; Activates expression of the rhaSR operon in response to L- rhamnose. | L-rhamnonate dehydratase; Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy- L-rhamnonate (KDR). Can also dehydrate L-lyxonate, L-mannonate and D- gulonate, although less efficiently, but not 2-keto-4-hydroxyheptane- 1,7-dioate; Belongs to the mandelate racemase/muconate lactonizing enzyme family. RhamD subfamily. | 0.802 |
rhmA | rhaM | b2245 | b3901 | 2-keto-3-deoxy-L-rhamnonate aldolase; Catalyzes the reversible retro-aldol cleavage of 2-keto-3- deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde. 2-keto-3-deoxy- L-mannonate, 2-keto-3-deoxy-L-lyxonate and 4-hydroxy-2-ketoheptane-1,7- dioate (HKHD) are also reasonably good substrates, although 2-keto-3- deoxy-L-rhamnonate is likely to be the physiological substrate. | L-rhamnose mutarotase; Involved in the anomeric conversion of L-rhamnose. | 0.551 |
rhmA | rhmD | b2245 | b2247 | 2-keto-3-deoxy-L-rhamnonate aldolase; Catalyzes the reversible retro-aldol cleavage of 2-keto-3- deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde. 2-keto-3-deoxy- L-mannonate, 2-keto-3-deoxy-L-lyxonate and 4-hydroxy-2-ketoheptane-1,7- dioate (HKHD) are also reasonably good substrates, although 2-keto-3- deoxy-L-rhamnonate is likely to be the physiological substrate. | L-rhamnonate dehydratase; Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy- L-rhamnonate (KDR). Can also dehydrate L-lyxonate, L-mannonate and D- gulonate, although less efficiently, but not 2-keto-4-hydroxyheptane- 1,7-dioate; Belongs to the mandelate racemase/muconate lactonizing enzyme family. RhamD subfamily. | 0.991 |
rhmA | rhmR | b2245 | b2248 | 2-keto-3-deoxy-L-rhamnonate aldolase; Catalyzes the reversible retro-aldol cleavage of 2-keto-3- deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde. 2-keto-3-deoxy- L-mannonate, 2-keto-3-deoxy-L-lyxonate and 4-hydroxy-2-ketoheptane-1,7- dioate (HKHD) are also reasonably good substrates, although 2-keto-3- deoxy-L-rhamnonate is likely to be the physiological substrate. | Putative DNA-binding transcriptional regulator for the rhm operon; Putative regulator; Protein involved in transcription and regulation of transcription, DNA-dependent. | 0.909 |
rhmA | rhmT | b2245 | b2246 | 2-keto-3-deoxy-L-rhamnonate aldolase; Catalyzes the reversible retro-aldol cleavage of 2-keto-3- deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde. 2-keto-3-deoxy- L-mannonate, 2-keto-3-deoxy-L-lyxonate and 4-hydroxy-2-ketoheptane-1,7- dioate (HKHD) are also reasonably good substrates, although 2-keto-3- deoxy-L-rhamnonate is likely to be the physiological substrate. | Putative L-rhamnonate transporter; Putative transport protein; Belongs to the major facilitator superfamily. Phthalate permease family. | 0.965 |
rhmD | glcD | b2247 | b2979 | L-rhamnonate dehydratase; Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy- L-rhamnonate (KDR). Can also dehydrate L-lyxonate, L-mannonate and D- gulonate, although less efficiently, but not 2-keto-4-hydroxyheptane- 1,7-dioate; Belongs to the mandelate racemase/muconate lactonizing enzyme family. RhamD subfamily. | Glycolate oxidase subunit, FAD-linked; Component of a complex that catalyzes the oxidation of glycolate to glyoxylate. Is required for E.coli to grow on glycolate as a sole source of carbon. Is also able to oxidize D-lactate ((R)-lactate) with a similar rate. Does not link directly to O(2), and 2,6-dichloroindophenol (DCIP) and phenazine methosulfate (PMS) can act as artificial electron acceptors in vitro, but the physiological molecule that functions as primary electron acceptor during glycolate oxidation is unknown ; Belongs to the FAD-binding oxidoreductase/transferase type 4 family. | 0.629 |