STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rhmDL-rhamnonate dehydratase; Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy- L-rhamnonate (KDR). Can also dehydrate L-lyxonate, L-mannonate and D- gulonate, although less efficiently, but not 2-keto-4-hydroxyheptane- 1,7-dioate; Belongs to the mandelate racemase/muconate lactonizing enzyme family. RhamD subfamily. (401 aa)    
Predicted Functional Partners:
rhmA
2-keto-3-deoxy-L-rhamnonate aldolase; Catalyzes the reversible retro-aldol cleavage of 2-keto-3- deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde. 2-keto-3-deoxy- L-mannonate, 2-keto-3-deoxy-L-lyxonate and 4-hydroxy-2-ketoheptane-1,7- dioate (HKHD) are also reasonably good substrates, although 2-keto-3- deoxy-L-rhamnonate is likely to be the physiological substrate.
 
 
 0.991
rhmT
Putative L-rhamnonate transporter; Putative transport protein; Belongs to the major facilitator superfamily. Phthalate permease family.
 
  
 0.967
rhmR
Putative DNA-binding transcriptional regulator for the rhm operon; Putative regulator; Protein involved in transcription and regulation of transcription, DNA-dependent.
 
  
 0.953
rhaM
L-rhamnose mutarotase; Involved in the anomeric conversion of L-rhamnose.
  
  
 0.821
gudD
D-glucarate dehydratase 1; Catalyzes the dehydration of glucarate to 5-keto-4-deoxy-D- glucarate (5-kdGluc). Also acts on L-idarate; Belongs to the mandelate racemase/muconate lactonizing enzyme family. GlucD subfamily.
      
 0.817
rhaR
Transcriptional activator of rhaSR; Activates expression of the rhaSR operon in response to L- rhamnose.
      
 0.802
rhaA
L-rhamnose isomerase; Protein involved in carbohydrate catabolic process.
      
 0.784
sgcB
Putative enzyme IIB component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.
  
    0.662
uxuA
Mannonate hydrolase; Catalyzes the dehydration of D-mannonate.
     
 0.632
glcD
Glycolate oxidase subunit, FAD-linked; Component of a complex that catalyzes the oxidation of glycolate to glyoxylate. Is required for E.coli to grow on glycolate as a sole source of carbon. Is also able to oxidize D-lactate ((R)-lactate) with a similar rate. Does not link directly to O(2), and 2,6-dichloroindophenol (DCIP) and phenazine methosulfate (PMS) can act as artificial electron acceptors in vitro, but the physiological molecule that functions as primary electron acceptor during glycolate oxidation is unknown ; Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
  
  
 0.629
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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