STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yfaYDoes not have nicotinamide-nucleotide (NMN) amidohydrolase activity (400 aa)    
Predicted Functional Partners:
pncC
Has nicotinamidemononucleotide (NMN) aminohydrolase activity, not active on other substrates
   
 0.957
ligT
Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester . In vitro, can also ligate 5' and 3' half-tRNA molecules with 2',3'-cyclic phosphate and 5'-hydroxyl termini, respectively, to the product containing the 2'-5' phosphodiester linkage. This reaction does not require ATP and is reversible .
 
  
 0.910
ydeJ
Does not have nicotinamide-nucleotide (NMN) amidohydrolase activity
    
 0.883
recA
Required for homologous recombination and the bypass of mutagenic DNA lesions by the SOS response. Catalyzes ATP-driven homologous pairing and strand exchange of DNA molecules necessary for DNA recombinational repair. Catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single- stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. The SOS response controls an apoptotic-like death (ALD) induced (in the absence of the mazE-mazF toxin-antitoxin module) in response to DNA damaging agents that is me [...]
     
 0.802
ycbJ
annotation not available
  
   
 0.652
yfjR
Uncharacterized HTH-type transcriptional regulator YfjR; Phage or Prophage Related
  
  
 0.626
yfaZ
annotation not available
       0.609
yfdN
Uncharacterized protein YfdN; CPS-53 (KpLE1) prophage; putative methyltransferase;Phage or Prophage Related
      
 0.605
ydcJ
Uncharacterized protein YdcJ; Putative enzyme; Not classified; To M.tuberculosis Rv3292
      
 0.603
yfeD
annotation not available
      
 0.601
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
Server load: low (4%) [HD]