node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aroC | epmC | b2329 | b2326 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. It uses NADPH to reduce FMN. | Elongation Factor P Lys34 hydroxylase; Is involved in the final hydroxylation step of the post- translational modification of translation elongation factor P (EF-P) on 'Lys-34'. Acts after beta-lysylation of 'Lys-34' by EpmA and EpmB. EpmC adds an oxygen atom to the C5 position of 'Lys-34' and does not modify the added beta-lysine. | 0.800 |
aroC | mepA | b2329 | b2328 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. It uses NADPH to reduce FMN. | Murein DD-endopeptidase; Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus and could also play a role in the integration of nascent murein strands into the sacculus. | 0.932 |
aroC | prmB | b2329 | b2330 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. It uses NADPH to reduce FMN. | N5-glutamine methyltransferase; Specifically methylates the 50S ribosomal protein L3 on 'Gln- 150'. Does not methylate the translation termination release factors RF1 and RF2; Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily. | 0.910 |
aroC | yfcA | b2329 | b2327 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. It uses NADPH to reduce FMN. | TauE/TSUP family inner membrane protein; Putative structural protein. | 0.809 |
aroC | yfcL | b2329 | b2325 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. It uses NADPH to reduce FMN. | Uncharacterized protein. | 0.712 |
dapE | prmB | b2472 | b2330 | N-succinyl-diaminopimelate deacylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | N5-glutamine methyltransferase; Specifically methylates the 50S ribosomal protein L3 on 'Gln- 150'. Does not methylate the translation termination release factors RF1 and RF2; Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily. | 0.601 |
epmC | aroC | b2326 | b2329 | Elongation Factor P Lys34 hydroxylase; Is involved in the final hydroxylation step of the post- translational modification of translation elongation factor P (EF-P) on 'Lys-34'. Acts after beta-lysylation of 'Lys-34' by EpmA and EpmB. EpmC adds an oxygen atom to the C5 position of 'Lys-34' and does not modify the added beta-lysine. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. It uses NADPH to reduce FMN. | 0.800 |
epmC | mepA | b2326 | b2328 | Elongation Factor P Lys34 hydroxylase; Is involved in the final hydroxylation step of the post- translational modification of translation elongation factor P (EF-P) on 'Lys-34'. Acts after beta-lysylation of 'Lys-34' by EpmA and EpmB. EpmC adds an oxygen atom to the C5 position of 'Lys-34' and does not modify the added beta-lysine. | Murein DD-endopeptidase; Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus and could also play a role in the integration of nascent murein strands into the sacculus. | 0.806 |
epmC | prmB | b2326 | b2330 | Elongation Factor P Lys34 hydroxylase; Is involved in the final hydroxylation step of the post- translational modification of translation elongation factor P (EF-P) on 'Lys-34'. Acts after beta-lysylation of 'Lys-34' by EpmA and EpmB. EpmC adds an oxygen atom to the C5 position of 'Lys-34' and does not modify the added beta-lysine. | N5-glutamine methyltransferase; Specifically methylates the 50S ribosomal protein L3 on 'Gln- 150'. Does not methylate the translation termination release factors RF1 and RF2; Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily. | 0.708 |
epmC | yfcA | b2326 | b2327 | Elongation Factor P Lys34 hydroxylase; Is involved in the final hydroxylation step of the post- translational modification of translation elongation factor P (EF-P) on 'Lys-34'. Acts after beta-lysylation of 'Lys-34' by EpmA and EpmB. EpmC adds an oxygen atom to the C5 position of 'Lys-34' and does not modify the added beta-lysine. | TauE/TSUP family inner membrane protein; Putative structural protein. | 0.973 |
epmC | yfcL | b2326 | b2325 | Elongation Factor P Lys34 hydroxylase; Is involved in the final hydroxylation step of the post- translational modification of translation elongation factor P (EF-P) on 'Lys-34'. Acts after beta-lysylation of 'Lys-34' by EpmA and EpmB. EpmC adds an oxygen atom to the C5 position of 'Lys-34' and does not modify the added beta-lysine. | Uncharacterized protein. | 0.921 |
mcbR | prmB | b1450 | b2330 | Colanic acid and biofilm gene transcriptional regulator, MqsR-controlled; Important for biofilm formation. Represses expression of McbA by binding to its promoter region, which prevents colanic acid overproduction and mucoidy. | N5-glutamine methyltransferase; Specifically methylates the 50S ribosomal protein L3 on 'Gln- 150'. Does not methylate the translation termination release factors RF1 and RF2; Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily. | 0.775 |
mepA | aroC | b2328 | b2329 | Murein DD-endopeptidase; Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus and could also play a role in the integration of nascent murein strands into the sacculus. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. It uses NADPH to reduce FMN. | 0.932 |
mepA | epmC | b2328 | b2326 | Murein DD-endopeptidase; Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus and could also play a role in the integration of nascent murein strands into the sacculus. | Elongation Factor P Lys34 hydroxylase; Is involved in the final hydroxylation step of the post- translational modification of translation elongation factor P (EF-P) on 'Lys-34'. Acts after beta-lysylation of 'Lys-34' by EpmA and EpmB. EpmC adds an oxygen atom to the C5 position of 'Lys-34' and does not modify the added beta-lysine. | 0.806 |
mepA | prmB | b2328 | b2330 | Murein DD-endopeptidase; Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus and could also play a role in the integration of nascent murein strands into the sacculus. | N5-glutamine methyltransferase; Specifically methylates the 50S ribosomal protein L3 on 'Gln- 150'. Does not methylate the translation termination release factors RF1 and RF2; Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily. | 0.895 |
mepA | yfcA | b2328 | b2327 | Murein DD-endopeptidase; Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus and could also play a role in the integration of nascent murein strands into the sacculus. | TauE/TSUP family inner membrane protein; Putative structural protein. | 0.954 |
mepA | yfcL | b2328 | b2325 | Murein DD-endopeptidase; Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus and could also play a role in the integration of nascent murein strands into the sacculus. | Uncharacterized protein. | 0.719 |
prfA | prfB | b1211 | b2891 | Peptide chain release factor RF-1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | Peptide chain release factor RF-2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. Acts as a peptidyl-tRNA hydrolase. In the presence of truncated mRNA in the 70S ribosome, ArfA and RF2 interact such that the GGQ peptide hydrolysis motif of RF2 rises into the peptidyl-transferase center and releases the ribosome. Recruited by ArfA to rescue stalled ribosomes in the absence of a normal stop codon. | 0.823 |
prfA | prmB | b1211 | b2330 | Peptide chain release factor RF-1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | N5-glutamine methyltransferase; Specifically methylates the 50S ribosomal protein L3 on 'Gln- 150'. Does not methylate the translation termination release factors RF1 and RF2; Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily. | 0.854 |
prfB | prfA | b2891 | b1211 | Peptide chain release factor RF-2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. Acts as a peptidyl-tRNA hydrolase. In the presence of truncated mRNA in the 70S ribosome, ArfA and RF2 interact such that the GGQ peptide hydrolysis motif of RF2 rises into the peptidyl-transferase center and releases the ribosome. Recruited by ArfA to rescue stalled ribosomes in the absence of a normal stop codon. | Peptide chain release factor RF-1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | 0.823 |