STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yfdRCPS-53 (KpLE1) prophage; 5'-deoxynucleotidase; Uncharacterized protein YfdR; Phage or Prophage Related (178 aa)    
Predicted Functional Partners:
yfdT
CPS-53 (KpLE1) prophage; protein YfdT; Uncharacterized protein YfdT; Phage or Prophage Related
  
  
 0.985
yfdQ
CPS-53 (KpLE1) prophage; protein YfdQ; Uncharacterized protein YfdQ; Phage or Prophage Related
 
  
 0.984
yfdS
Uncharacterized protein YfdS; Phage or Prophage Related; To the N-terminal region of phage HK97/HK620 Gp37/hpaH
     
 0.983
ymfL
E14 prophage; uncharacterized protein YmfL; Uncharacterized protein YmfL; Phage or Prophage Related
  
   
 0.947
ydfR
Qin prophage; protein ydfr; Uncharacterized protein YdfR; Phage or Prophage Related
      
 0.878
yfdP
CPS-53 (KpLE1) prophage; protein YfdP; To phage T4 y06Q
 
   
 0.878
yfbR
5'-deoxynucleotidase; Essential component of the deoxycytidine triphosphate (dCTP) pathway for de novo synthesis of thymidylate. Catalyzes the strictly specific dephosphorylation of 2'-deoxyribonucleoside 5'-monophosphates (dAMP, dGMP, dTMP, dUMP, dIMP and dCMP) and does not dephosphorylate 5'-ribonucleotides or ribonucleoside 3'-monophosphates
      
 0.875
hda
Atpase regulatory factor involved in dnaa inactivation; Mediates the interactions of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA. ADP-binding activates Hda to hydrolyze DnaA-ATP; Hda monomers bind to ADP with about 200-fold greater affinity than for ATP. RIDA function can be genetically separated from viability, suggesting this protein has another function as well
     
 0.796
diaA
Dnaa initiator-associating factor for replication initiation; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein
     
 0.737
dnaB
Replicative dna helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins
     
 0.610
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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