node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
acrA | acrD | b0463 | b2470 | Multidrug efflux pump membrane fusion lipoprotein acra; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm | Multidrug efflux pump rnd permease acrd; Participates in the efflux of aminoglycosides. Confers resistance to a variety of these substances | 0.999 |
acrA | baeR | b0463 | b2079 | Multidrug efflux pump membrane fusion lipoprotein acra; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm | Member of the two-component regulatory system BaeS/BaeR which responds to envelope stress . Activates expression of periplasmic chaperone spy in response to spheroplast formation, indole and P pili protein PapG overexpression . Activates the mdtABCD and probably the CRISPR-Cas casABCDE-ygbT-ygbF operon | 0.547 |
acrA | cusC | b0463 | b0572 | Multidrug efflux pump membrane fusion lipoprotein acra; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm | Copper/silver efflux system, outer membrane component; Forms pores that allow passive diffusion of cations across the outer membrane. Part of a cation efflux system that mediates resistance to copper and silver. In pathogenic strains it allows the bacteria to invade brain microvascular endothelial cells (BMEC) thus allowing it to cross the blood-brain barrier and cause neonatal meningitis | 0.964 |
acrA | emrD | b0463 | b3673 | Multidrug efflux pump membrane fusion lipoprotein acra; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm | Mfs transporter, dha1 family, 2-module integral membrane pump emrd; Multidrug resistance pump that participates in a low energy shock adaptive response | 0.729 |
acrA | emrK | b0463 | b2368 | Multidrug efflux pump membrane fusion lipoprotein acra; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm | Multidrug resistance efflux pump membrane fusion protein; Part of the tripartite efflux system EmrYK-TolC, which confers resistance to various drugs | 0.718 |
acrA | macB | b0463 | b0879 | Multidrug efflux pump membrane fusion lipoprotein acra; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm | Abc-type tripartite efflux pump atp binding/membrane subunit; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. When overexpressed, the system confers resistance against macrolides composed of 14- and 15-membered lactones but no or weak resistance against 16-membered ones. In addition, the system could also transport R-LPS or a similar glycolipid | 0.939 |
acrA | mdtA | b0463 | b2074 | Multidrug efflux pump membrane fusion lipoprotein acra; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm | Multidrug efflux pump membrane fusion protein mdta; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function | 0.715 |
acrA | tolC | b0463 | b3035 | Multidrug efflux pump membrane fusion lipoprotein acra; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm | Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells | 0.999 |
acrD | acrA | b2470 | b0463 | Multidrug efflux pump rnd permease acrd; Participates in the efflux of aminoglycosides. Confers resistance to a variety of these substances | Multidrug efflux pump membrane fusion lipoprotein acra; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm | 0.999 |
acrD | acrE | b2470 | b3265 | Multidrug efflux pump rnd permease acrd; Participates in the efflux of aminoglycosides. Confers resistance to a variety of these substances | Multidrug efflux pump membrane fusion lipoprotein acre; Part of the tripartite efflux system AcrEF-TolC. Involved in the efflux of indole and organic solvents | 0.872 |
acrD | baeR | b2470 | b2079 | Multidrug efflux pump rnd permease acrd; Participates in the efflux of aminoglycosides. Confers resistance to a variety of these substances | Member of the two-component regulatory system BaeS/BaeR which responds to envelope stress . Activates expression of periplasmic chaperone spy in response to spheroplast formation, indole and P pili protein PapG overexpression . Activates the mdtABCD and probably the CRISPR-Cas casABCDE-ygbT-ygbF operon | 0.840 |
acrD | cusC | b2470 | b0572 | Multidrug efflux pump rnd permease acrd; Participates in the efflux of aminoglycosides. Confers resistance to a variety of these substances | Copper/silver efflux system, outer membrane component; Forms pores that allow passive diffusion of cations across the outer membrane. Part of a cation efflux system that mediates resistance to copper and silver. In pathogenic strains it allows the bacteria to invade brain microvascular endothelial cells (BMEC) thus allowing it to cross the blood-brain barrier and cause neonatal meningitis | 0.904 |
acrD | emrD | b2470 | b3673 | Multidrug efflux pump rnd permease acrd; Participates in the efflux of aminoglycosides. Confers resistance to a variety of these substances | Mfs transporter, dha1 family, 2-module integral membrane pump emrd; Multidrug resistance pump that participates in a low energy shock adaptive response | 0.832 |
acrD | emrK | b2470 | b2368 | Multidrug efflux pump rnd permease acrd; Participates in the efflux of aminoglycosides. Confers resistance to a variety of these substances | Multidrug resistance efflux pump membrane fusion protein; Part of the tripartite efflux system EmrYK-TolC, which confers resistance to various drugs | 0.863 |
acrD | macB | b2470 | b0879 | Multidrug efflux pump rnd permease acrd; Participates in the efflux of aminoglycosides. Confers resistance to a variety of these substances | Abc-type tripartite efflux pump atp binding/membrane subunit; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. When overexpressed, the system confers resistance against macrolides composed of 14- and 15-membered lactones but no or weak resistance against 16-membered ones. In addition, the system could also transport R-LPS or a similar glycolipid | 0.883 |
acrD | mdtA | b2470 | b2074 | Multidrug efflux pump rnd permease acrd; Participates in the efflux of aminoglycosides. Confers resistance to a variety of these substances | Multidrug efflux pump membrane fusion protein mdta; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function | 0.969 |
acrD | mdtE | b2470 | b3513 | Multidrug efflux pump rnd permease acrd; Participates in the efflux of aminoglycosides. Confers resistance to a variety of these substances | Anaerobic multidrug efflux transporter, arca-regulated; Part of the tripartite efflux system MdtEF-TolC, which confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzalkonium | 0.972 |
acrD | tolC | b2470 | b3035 | Multidrug efflux pump rnd permease acrd; Participates in the efflux of aminoglycosides. Confers resistance to a variety of these substances | Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells | 0.984 |
acrE | acrD | b3265 | b2470 | Multidrug efflux pump membrane fusion lipoprotein acre; Part of the tripartite efflux system AcrEF-TolC. Involved in the efflux of indole and organic solvents | Multidrug efflux pump rnd permease acrd; Participates in the efflux of aminoglycosides. Confers resistance to a variety of these substances | 0.872 |
acrE | cusC | b3265 | b0572 | Multidrug efflux pump membrane fusion lipoprotein acre; Part of the tripartite efflux system AcrEF-TolC. Involved in the efflux of indole and organic solvents | Copper/silver efflux system, outer membrane component; Forms pores that allow passive diffusion of cations across the outer membrane. Part of a cation efflux system that mediates resistance to copper and silver. In pathogenic strains it allows the bacteria to invade brain microvascular endothelial cells (BMEC) thus allowing it to cross the blood-brain barrier and cause neonatal meningitis | 0.875 |