STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hyfHHydrogenase 4, fe-s subunit; Probable electron transfer protein for hydrogenase 4 (181 aa)    
Predicted Functional Partners:
nuoC
Nadh:ubiquinone oxidoreductase, fused cd subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
 
 0.999
nuoB
Nadh:ubiquinone oxidoreductase, chain b; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
 0.989
hyfG
Hydrogenase 4 catalytic subunit hyfg; Possible component of hydrogenase 4
 
   0.980
hyfI
Hydrogenase 4 catalytic subunit hyfi; Possible component of hydrogenase 4
   0.978
pfo
Pyruvate-ferredoxin/flavodoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
  
 
 0.976
hyfD
Hydrogenase 4, membrane subunit; Possible component of hydrogenase 4
 
 
 0.967
hyfJ
Putative processing element hydrogenase 4; Possible component of hydrogenase 4
    0.962
hyfF
Hydrogenase 4, membrane subunit; Possible component of hydrogenase 4
 
   0.958
hyfC
Hydrogenase 4, membrane subunit; Possible component of hydrogenase 4
 
   0.957
hyfB
Hydrogenase 4, membrane subunit; Possible component of hydrogenase 4
 
   0.947
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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