STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hyfJPutative processing element hydrogenase 4; Possible component of hydrogenase 4 (137 aa)    
Predicted Functional Partners:
hyfG
Hydrogenase 4 catalytic subunit hyfg; Possible component of hydrogenase 4
 
  
 0.992
hyfI
Hydrogenase 4 catalytic subunit hyfi; Possible component of hydrogenase 4
    0.968
hyfR
Dna-binding transcriptional activator hyfr; A transcriptional activator of its own operon; when overexpressed operon expression is strongly enhanced by low pH (under pH 6.0), strongly inhibited by O(2) but only weakly stimulated by fumarate . Expression in situ is very weak
 
   
 0.965
hyfE
Hydrogenase 4, membrane subunit; Possible component of hydrogenase 4
 
     0.964
hyfF
Hydrogenase 4, membrane subunit; Possible component of hydrogenase 4
 
    0.964
hyfH
Hydrogenase 4, fe-s subunit; Probable electron transfer protein for hydrogenase 4
    0.962
hyfC
Hydrogenase 4, membrane subunit; Possible component of hydrogenase 4
 
    0.957
hyfA
Hydrogenase 4, 4fe-4s subunit; Probable electron transfer protein for hydrogenase 4
 
  
 0.956
hyfB
Hydrogenase 4, membrane subunit; Possible component of hydrogenase 4
 
    0.951
hyfD
Hydrogenase 4, membrane subunit; Possible component of hydrogenase 4
 
     0.951
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
Server load: low (8%) [HD]