STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hyfRDna-binding transcriptional activator hyfr; A transcriptional activator of its own operon; when overexpressed operon expression is strongly enhanced by low pH (under pH 6.0), strongly inhibited by O(2) but only weakly stimulated by fumarate . Expression in situ is very weak (670 aa)    
Predicted Functional Partners:
hyfJ
Putative processing element hydrogenase 4; Possible component of hydrogenase 4
 
   
 0.965
focB
Putative formate transporter; Involved in the bidirectional transport of formate
     
 0.937
hyfG
Hydrogenase 4 catalytic subunit hyfg; Possible component of hydrogenase 4
     
 0.893
hyfA
Hydrogenase 4, 4fe-4s subunit; Probable electron transfer protein for hydrogenase 4
 
   
 0.818
hyfF
Hydrogenase 4, membrane subunit; Possible component of hydrogenase 4
 
 
   0.802
hyfE
Hydrogenase 4, membrane subunit; Possible component of hydrogenase 4
 
     0.798
hyfH
Hydrogenase 4, fe-s subunit; Probable electron transfer protein for hydrogenase 4
     
 0.797
rpoN
Rna polymerase, sigma 54 (sigma n) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of enzymes involved in arginine catabolism. The open complex (sigma-54 and core RNA polymerase) serves as the receptor for the receipt of the melting signal from the remotely bound activator protein GlnG(NtrC)
  
   
 0.788
hyfD
Hydrogenase 4, membrane subunit; Possible component of hydrogenase 4
 
    0.766
hyfI
Hydrogenase 4 catalytic subunit hyfi; Possible component of hydrogenase 4
  
    0.758
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.