STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yfgHPutative outer membrane lipoprotein. (172 aa)    
Predicted Functional Partners:
yceK
Outer membrane integrity lipoprotein; To E.coli YidQ.
      
 0.802
yfgI
Nalidixic acid resistance protein, putative periplasmic protein; Putative membrane protein.
  
    0.767
hdeD
Acid-resistance membrane protein.
  
    0.752
tamB
Translocation and assembly module for autotransporter export, inner membrane subunit; Part of the translocation and assembly module (TAM) autotransporter assembly complex, which functions in translocation of autotransporters across the outer membrane. In reconstituted TAM this subunit (Ag43, AC P39180) is not necessary for substrate penetration in the outer membrane. Substrate binding to TamA moves its POTRA domains about 30 Angstroms into the periplasm, which would deform either the outer membrane or TamB and may provide force to reset TAM.
  
   
 0.581
appA
Phosphoanhydride phosphorylase; pH 2.5 acid phosphatase; periplasmic; Protein involved in phosphorus metabolic process and response to starvation.
  
     0.556
gfcC
Putative O-antigen capsule production periplasmic protein; To E.coli YjbG.
  
    0.505
yeeJ
Putative factor; Protein involved in regulation of transcription, DNA-dependent; Belongs to the intimin/invasin family.
  
     0.502
ydeO
UV-inducible global regulator, EvgA-, GadE-dependent; Induces the expression of gadE and mdtEF. Could also regulate the expression of other genes involved in acid resistance.
  
    0.476
ompA
Outer membrane protein A (3a;II*;G;d); With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm (Probable). Plays a role in resistance to environmental stress, and a role in outer membrane functionality and cell shape. Non-covalently binds peptidoglycan (Probable). Acts as a porin with low permeability that allows slow penetration of small solutes. A very abundant protein, there can be up to 210,000 OmpA molecules per cell. Reconstitution in unilamellar lipid vesicles shows only about 3% of the protein is in an open conformation, whic [...]
   
  
 0.475
gfcB
O-antigen capsule production lipoprotein; Putative regulator.
  
     0.445
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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