STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pbpCPenicillin-binding protein 1C; Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional (770 aa)    
Predicted Functional Partners:
yfhM
annotation not available
 
 0.998
ftsI
Peptidoglycan D,D-transpeptidase FtsI; Essential cell division protein that catalyzes cross- linking of the peptidoglycan cell wall at the division septum. Required for localization of FtsN; Belongs to the transpeptidase family. FtsI subfamily
     
 0.940
ampH
D-alanyl-D-alanine-carboxypeptidase/endopeptidase AmpH; Hydrolyzes the cross-linked dimers tetrapentapeptide (D45) and tetratetrapeptide (D44). Removes the terminal D-alanine from muropeptides and disaccharide pentapeptide M5 with a C- terminal D-Ala-D-Ala dipeptide. Associated with recycling and remodeling of peptidoglycan (PG). Also displays a low beta- lactamase activity; Belongs to the beta-lactamase family
  
  
 0.922
mrdA
Peptidoglycan D,D-transpeptidase MrdA; Catalyzes cross-linking of the peptidoglycan cell wall. Responsible for the determination of the rod shape of the cell. Is probably required for lateral peptidoglycan synthesis and maintenance of the correct diameter during lateral and centripetal growth; Belongs to the transpeptidase family. MrdA subfamily
     
 0.917
mrcB
Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits); In the N-terminal section; belongs to the glycosyltransferase 51 family
  
  
0.914
mrcA
Penicillin-binding protein 1A; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits); In the N-terminal section; belongs to the glycosyltransferase 51 family
  
  
0.914
dacA
D-alanyl-D-alanine carboxypeptidase DacA; Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors
     
 0.910
dacC
D-alanyl-D-alanine carboxypeptidase DacC; Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors
     
 0.910
dacD
D-alanyl-D-alanine carboxypeptidase DacD; Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; Belongs to the peptidase S11 family
     
 0.910
yfeW
UPF0214 protein YfeW; Putative beta-lactamase; Protein involved in carbohydrate catabolic process; Belongs to the UPF0214 family
     
 0.903
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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