STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hcaTMfs transporter, ppp family, 3-phenylpropionic acid transporter; Probable permease involved in the uptake of 3-phenylpropionic acid (379 aa)    
Predicted Functional Partners:
idnT
L-idonate/5-ketogluconate/gluconate transporter; Transports L-idonate, D-gluconate and 5-keto-D-gluconate, from the periplasm across the inner membrane
      
 0.906
cysG
Uroporphyrin-iii c-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
     
 0.901
hcaR
Lysr family transcriptional regulator, hca operon transcriptional activator; Transcriptional activator of the hca operon for 3- phenylpropionic acid catabolism
  
   0.537
ihfB
Integration host factor (ihf), dna-binding protein, beta subunit; One of the 2 subunits of integration host factor (IHF), a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Has an essential role in conjugative DNA transfer (CDT), the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations. Part of the relaxosome, which facilitates a site- and strand-specific cut in the ori [...]
   
 
 0.532
pflC
Putative [formate-c-acetyltransferase 2]-activating enzyme; Activation of pyruvate formate-lyase 2 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
      
 0.520
rssA
Putative patatin-like family phospholipase; Belongs to the NTE family
 
  
 0.514
yfbU
annotation not available
  
     0.436
ybfA
annotation not available
  
     0.418
ninE
DLP12 prophage; NinE family prophage protein; Prophage NinE homolog; Similar to phage 82 and lambda proteins
      
 0.416
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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