STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ygaHannotation not available (111 aa)    
Predicted Functional Partners:
ygaZ
L-valine exporter subunit ygaz; Inner membrane protein YgaZ; Pseudogene, major facilitator transporter superfamily;putative transport; Not classified; putative transport protein; Protein involved in response to stress
 
 
  0.997
mprA
Marr family transcriptional regulator, negative regulator of the multidrug operon emrrab; Negative regulator of the multidrug operon emrAB
  
  
 0.822
mlaE
Abc transporter maintaining om lipid asymmetry, inner membrane permease protein; Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for the translocation of the substrate across the membrane
      
 0.704
ilvL
Ilvxgmeda operon leader peptide; ilvGEDA operon leader peptide
      
 0.677
yebW
annotation not available
  
     0.557
nohD
Terminase small subunit / prophage dna-packing protein; DNA-packaging protein NU1 homolog; Bacteriophage DNA packaging protein
  
     0.489
yddM
Putative dna-binding transcriptional regulator yddm; Belongs to the VapA/VapI family
  
     0.476
emrA
Multidrug efflux pump membrane fusion protein emra; Part of the tripartite efflux system EmrAB-TolC, which confers resistance to antibiotics such as CCCP, FCCP, 2,4-dinitrophenol and nalidixic acid. EmrA is a drug-binding protein that provides a physical link between EmrB and TolC
   
   0.432
rne
Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Can also process other RNA species, such as RNAI, a molecule that controls the replication of ColE1 plasmid, and the cell division inhibitor DicF- RNA. It initiates the decay of RNAs by cutting them internally near their 5'-end. It is able to remove poly(A) tails by an endonucleolytic process. Required to initiate rRNA degradation during both starvation and quality control; acts after RNase PH [...]
      
 0.422
yjjZ
annotation not available
  
     0.413
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.