STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
emrBMultidrug export protein EmrB; Part of the tripartite efflux system EmrAB-TolC, which confers resistance to antibiotics such as CCCP, FCCP, 2,4- dinitrophenol and nalidixic acid (512 aa)    
Predicted Functional Partners:
emrA
Multidrug export protein EmrA; Part of the tripartite efflux system EmrAB-TolC, which confers resistance to antibiotics such as CCCP, FCCP, 2,4- dinitrophenol and nalidixic acid. EmrA is a drug-binding protein that provides a physical link between EmrB and TolC; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
 
 0.999
tolC
Outer membrane protein TolC; Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells
    
 0.972
macB
Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. When overexpressed, the system confers resistance against macrolides composed of 14- and 15-membered lactones but no or weak resistance against 16-membered ones. In addition, the system could also transport R-LPS or a similar glycolipid; Belongs to the ABC transporter superfamily. Macrolid [...]
   
 
 0.877
emrK
Probable multidrug resistance protein EmrK; Part of the tripartite efflux system EmrYK-TolC, which confers resistance to various drugs
 
 
 0.859
mprA
Transcriptional repressor MprA; Negative regulator of the multidrug operon emrAB
 
 
 0.826
acrA
Multidrug efflux pump subunit AcrA; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm
   
 
 0.789
acrD
Probable aminoglycoside efflux pump; Participates in the efflux of aminoglycosides. Confers resistance to a variety of these substances
    
 
 0.785
mdtF
Multidrug resistance protein MdtF; Part of the tripartite efflux system MdtEF-TolC, which confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzalkonium; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
    
 
 0.732
acrE
Multidrug export protein AcrE; Part of the tripartite efflux system AcrEF-TolC. Involved in the efflux of indole and organic solvents; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
   
 
 0.731
acrF
Multidrug export protein AcrF; Part of the tripartite efflux system AcrEF-TolC. Involved in the efflux of indole and organic solvents; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
    
 
 0.731
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
Server load: low (6%) [HD]